Development and Validation of an Analytical Methodology Based on Liquid Chromatography-Electrospray Tandem Mass Spectrometry for the Simultaneous Determination of Phenolic Compounds in Olive Leaf Extract

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dc.contributor.authorCittan, M
dc.contributor.authorÇelik, A
dc.date.accessioned2024-07-18T11:46:19Z
dc.date.available2024-07-18T11:46:19Z
dc.description.abstractA simple method was validated for the analysis of 31 phenolic compounds using liquid chromatography-electrospray tandem mass spectrometry. Proposed method was successfully applied to the determination of phenolic compounds in an olive leaf extract and 24 compounds were analyzed quantitatively. Olive biophenols were extracted from olive leaves by using microwave-assisted extraction with acceptable recovery values between 78.1 and 108.7%. Good linearities were obtained with correlation coefficients over 0.9916 from calibration curves of the phenolic compounds. The limits of quantifications were from 0.14 to 3.2 mu g g(-1). Intra-day and inter-day precision studies indicated that the proposed method was repeatable. As a result, it was confirmed that the proposed method was highly reliable for determination of the phenolic species in olive leaf extracts.
dc.identifier.issn0021-9665
dc.identifier.other1945-239X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/2648
dc.language.isoEnglish
dc.publisherOXFORD UNIV PRESS INC
dc.subjectULTRASOUND-ASSISTED EXTRACTION
dc.subjectRESPONSE-SURFACE METHODOLOGY
dc.subjectOLEA-EUROPAEA L.
dc.subjectGAS-CHROMATOGRAPHY
dc.subjectPESTICIDE-RESIDUES
dc.subjectLEAVES
dc.subjectOLEUROPEIN
dc.subjectSEPARATION
dc.subjectOPTIMIZATION
dc.subjectBIOPHENOLS
dc.titleDevelopment and Validation of an Analytical Methodology Based on Liquid Chromatography-Electrospray Tandem Mass Spectrometry for the Simultaneous Determination of Phenolic Compounds in Olive Leaf Extract
dc.typeArticle

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