Glukagon like peptid-1

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dc.contributor.authorGüclü, F
dc.contributor.authorÖzmen, B
dc.contributor.authorHekimsoy, Z
dc.contributor.authorKafesciler, SÖ
dc.date.accessioned2024-07-18T11:40:27Z
dc.date.available2024-07-18T11:40:27Z
dc.description.abstractGlucagon-like peptide-1 (GLP-1) is a 30 amino-acid hormone produced by the pancreatic islet alpha cells, intestinal-L cells and central nervous sytem cells. The main target of action of GLP-1 is the islet, where the hormone stimulates insulin secretion, promotes beta cell proliferation and neogenesis, and inhibits glucagon secretion. However, GLP-1 receptors are also expressed outside the islets, increasing the likelihood that GLP-1 also plays a role in other organs. These functions are mainly the inhibition of gastric emptying, gastric acid secretion and exocrine pancreatic secretion, indicating that the hormone acts as an enterogastrone hormone released from the distal portion of the small intestine that inhibits proximal gastrointestinal events. Another important action of GLP-1 is to induce satiety. Other effects of the hormone include cardioprotection, neuroprotection, induction of antidiabetic actions unrelated to islet function. Thus, GLP-1 clearly has several manifestations of activity. The physiological relevance of these actions and their contribution to the overall antidiabetic action of GLP-1 when used in treatment of type 2 diabetes remains to be established.
dc.identifier.issn1300-0292
dc.identifier.other2146-9040
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/2438
dc.language.isoTurkish
dc.publisherORTADOGU AD PRES & PUBL CO
dc.subjectGLUCAGON-LIKE PEPTIDE-1
dc.subjectBETA-CELL FUNCTION
dc.subjectMETFORMIN-TREATED PATIENTS
dc.subjectTYPE-2 DIABETES-MELLITUS
dc.subjectGLYCEMIC CONTROL
dc.subjectEXENATIDE EXENDIN-4
dc.subjectPOSTPRANDIAL GLUCOSE
dc.subjectINSULIN-SECRETION
dc.subjectINCRETIN HORMONES
dc.subjectGLP-1
dc.titleGlukagon like peptid-1
dc.typeReview

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