Synthesis, characterization and radiolabeling of folic acid modified nanostructured lipid carriers as a contrast agent and drug delivery system

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dc.contributor.authorUcar E.
dc.contributor.authorTeksoz S.
dc.contributor.authorIchedef C.
dc.contributor.authorKilcar A.Y.
dc.contributor.authorMedine E.I.
dc.contributor.authorAri K.
dc.contributor.authorParlak Y.
dc.contributor.authorSayit Bilgin B.E.
dc.contributor.authorUnak P.
dc.date.accessioned2024-07-22T08:11:21Z
dc.date.available2024-07-22T08:11:21Z
dc.date.issued2017
dc.description.abstractNanostructured lipid carriers (NLCs) are the new generation of solid lipid drug delivery systems. Their suitability as contrast agents for gamma scintigraphy is an attracting major attention. The aim of current study was to prepare surface modified nanostructured lipid carrier system for paclitaxel (PTX) with active targeting and imaging functions. In accordance with the purpose of study, PTX loaded nanostructured lipid carriers (NLCs) prepared, modified with a folate derivative and radiolabeled with technetium-99 m tricarbonyl complex (99 mTc(CO)3 +). Cellular incorporation ratios of radiolabeled nanoparticles (99 mTc(CO)3-PTX-NLC) were investigated in vitro on three cancer cell lines. Additionally in vivo animal studies conducted to evaluate biological behavior of 99 mTc(CO)3-PTX-NLC on female Wistar Albino rats. Biodistribution results showed that the folate derivative modified 99 mTc(CO)3-PTX-NLC had considerably higher uptake in folate receptor positive organs. The data obtained from present study could be useful in the design of biodegradable drug carriers of PTX and folate receptor based tumor imaging agents. © 2016 Elsevier Ltd
dc.identifier.DOI-ID10.1016/j.apradiso.2016.11.002
dc.identifier.issn09698043
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15626
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.subjectA549 Cells
dc.subjectAnimals
dc.subjectContrast Media
dc.subjectDrug Carriers
dc.subjectDrug Delivery Systems
dc.subjectFemale
dc.subjectFolic Acid
dc.subjectHeLa Cells
dc.subjectHumans
dc.subjectLipids
dc.subjectMCF-7 Cells
dc.subjectMicroscopy, Fluorescence
dc.subjectNanostructures
dc.subjectPaclitaxel
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTechnetium
dc.subjectTissue Distribution
dc.subjectCell culture
dc.subjectNuclear medicine
dc.subjectTargeted drug delivery
dc.subjectTechnetium compounds
dc.subjectfolate receptor
dc.subjectfolic acid
dc.subjectpaclitaxel
dc.subjectradioisotope
dc.subjectsolid lipid nanoparticle
dc.subjecttechnetium tricarbonyl complex tc 99m
dc.subjectunclassified drug
dc.subjectcontrast medium
dc.subjectdrug carrier
dc.subjectfolic acid
dc.subjectlipid
dc.subjectnanomaterial
dc.subjectpaclitaxel
dc.subjecttechnetium
dc.subjectBiodistributions
dc.subjectNanostructured lipid carriers
dc.subjectPaclitaxel
dc.subjectRadiolabeling
dc.subjectTechnetium-99m
dc.subjectanimal experiment
dc.subjectArticle
dc.subjectcell viability
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectdispersity
dc.subjectdrug absorption
dc.subjectdrug delivery system
dc.subjectdrug distribution
dc.subjectdrug purity
dc.subjectdrug synthesis
dc.subjectfemale
dc.subjectfluorescence microscopy
dc.subjecthuman
dc.subjecthuman cell
dc.subjectisotope labeling
dc.subjectnanotechnology
dc.subjectnonhuman
dc.subjectparticle size
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectproton nuclear magnetic resonance
dc.subjectrat
dc.subjecttissue distribution
dc.subjecttransmission electron microscopy
dc.subjectWistar rat
dc.subjectzeta potential
dc.subjectA-549 cell line
dc.subjectanimal
dc.subjectchemistry
dc.subjectHeLa cell line
dc.subjectMCF-7 cell line
dc.subjectsynthesis
dc.subjectControlled drug delivery
dc.titleSynthesis, characterization and radiolabeling of folic acid modified nanostructured lipid carriers as a contrast agent and drug delivery system
dc.typeArticle

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