Chromatographic profile and antioxidant and enzyme inhibitory activity of Sideritis leptoclada: An endemic plant from Turkey
| dc.contributor.author | Sarikurkcu C. | |
| dc.contributor.author | Ozer M.S. | |
| dc.contributor.author | Istifli E.S. | |
| dc.contributor.author | Sahinler S.S. | |
| dc.contributor.author | Tepe B. | |
| dc.date.accessioned | 2025-04-10T11:05:05Z | |
| dc.date.available | 2025-04-10T11:05:05Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Sideritis species have been used for centuries for their antimicrobial, digestive, anti-ulcerogenic and anti-inflammatory properties. Therefore, in this study, it was aimed to evaluate the chemical composition, antioxidant and enzyme inhibitory activities of solvent extracts of S. leptoclada O. Schwarz & P.H. Davis, an endemic species. It was determined that methanol (MeOH) and water extracts contained high amounts of chlorogenic acid and verbascoside, while the ethyl acetate (EtOAc) extract contained high amounts of 4-hydroxybenzoic and vanilic acids. The water extract showed the highest antioxidant activity in almost all parameters. Inhibitory activity of the MeOH extract on tyrosinase was 1.04 mg/ml, which was the highest value in this experiment. On the other hand, in α-amylase inhibitory assay, the EtOAc extract showed an activity of 2.21 mg/ml. Docking analysis showed that verbascoside can be an effective tyrosinase and α-amylase inhibitory agent. © 2021 SAAB | |
| dc.identifier.DOI-ID | 10.1016/j.sajb.2021.03.020 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/45802 | |
| dc.publisher | Elsevier B.V. | |
| dc.title | Chromatographic profile and antioxidant and enzyme inhibitory activity of Sideritis leptoclada: An endemic plant from Turkey | |
| dc.type | Article |