Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3

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dc.contributor.authorErsoy, B
dc.contributor.authorOzbilgin, K
dc.contributor.authorKasirga, E
dc.contributor.authorInan, S
dc.contributor.authorCoskun, S
dc.contributor.authorTuglu, I
dc.date.accessioned2024-07-18T11:49:51Z
dc.date.available2024-07-18T11:49:51Z
dc.description.abstractAIM: To evaluate the effects of growth hormone (GH) on the histology of small intestines which might be related to the role of insulin like growth factor (IGF)-I, IGF-binding protein 3 (IGFBP-3) and its receptors. METHODS: Twelve week-old adult male Wistar albino rats were divided into two groups. The study group (n = 10), received recombinant human growth hormone (rGH) at a dose of 2 mg/kg per day subcutaneously for 14 d and the control group (n = 10) received physiologic serum. Paraffin sections of jejunum were stained with periodic acid shift (PAS) and hematoxylin and eosin (HE) for light microscopy. They were also examined for IGF-I, IGFBP-3 and IGF-receptor immunoreactivities. Staining intensity was graded semi-quantitatively using the HS-CORE. RESULTS: Goblet cells and the cells in crypt epithelia were significantly increased in the study group compared to that of the control group. We have demonstrated an increase of IGF-I and IGFBP-3 immunoreactivities in surface epithelium of the small intestine by GH application. IGF-I receptor immunoreactivities of crypt, villous columnar cells, enteroendocrine cells and muscularis mucosae were also more strongly positive in the study group compared to those of in the control group. CONCLUSION: These findings confirm the important trophic and protective role of GH in the homeostasis of the small intestine. The trophic effect is mediated by an increase in IGF-I synthesis in the small intestine, but the protective effect is not related to IGF-I. (C) 2009 The WIG Press and Baishideng. All rights reserved.
dc.identifier.issn1007-9327
dc.identifier.other2219-2840
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/4347
dc.language.isoEnglish
dc.publisherBAISHIDENG PUBLISHING GROUP INC
dc.subjectSHORT-BOWEL SYNDROME
dc.subjectTRANSFORMING ACTIVITIES
dc.subjectFACTOR RECEPTOR
dc.subjectTROPHIC ACTION
dc.subjectINSULIN
dc.subjectRAT
dc.subjectGLUTAMINE
dc.subjectMUCOSA
dc.subjectLOCALIZATION
dc.subjectADAPTATION
dc.titleEffect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3
dc.typeArticle

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