Effect of intra-abdominal boric acid in the experimental adhesion model; [Deneysel adeyon modelinde, entraabdominal borik asidin etkisi]
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2024
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Abstract
BACKGROUND: The continuous advancement in medical and surgical techniques has led to a rise in the frequency of abdominal operations, subsequently increasing the incidence of intra-abdominal adhesions. Over 90% of laparotomies result in postoperative intra-abdominal adhesions. This study investigates the effect of a 5% boric acid solution on the development of intra-abdominal adhesions in rats, using an adhesion model. METHODS: This study was conducted with two groups: a control group, in which the adhesion model was applied without any treatment, and a boric acid group, which was treated with a 5% boric acid solution. Each group comprised 16 rats. On the 14th postoperative day, the rats were sacrificed, re-explored, and the developed adhesions were evaluated both macroscopically and microscopically. The data from macroscopic and microscopic scoring were analyzed using the Mann-Whitney U test in the IBM Statistical Package for the Social Sciences (SPSS) Statistics 24 program. A p-value of less than 0.05 was considered statistically significant. This research was supported by the Manisa Celal Bayar University Scientific Research Projects Commission. RESULTS: A statistically significant difference was observed between the boric acid-treated group and the control group, with the boric acid group showing a significant decrease in adhesion development both macroscopically and microscopically (p<0.05). CONCLUSION: In the future, boron could play a significant role in reducing and preventing intra-abdominal adhesions after surgery. This investigation could pave the way for further research into the mechanism by which boric acid prevents the development of intra-abdominal adhesions. Moreover, it is imperative to explore the potential side effects of intra-abdominal boron application at the optimum concentration of the solution. © 2024, Turkish Association of Trauma and Emergency Surgery. All rights reserved.
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Abdominal Cavity , Animals , Boric Acids , Boron , Humans , Laparotomy , Rats , Tissue Adhesions , boric acid , boron , ketamine , xylazine , boric acid , abdomen , abdominal surgery , adhesion , animal experiment , animal model , animal tissue , Article , controlled study , diagnostic procedure , experimental adhesion model , female , fibrosis , humidity , immunohistochemistry , inflammation , intra abdominal adhesions , macroscopy , microscopy , nonhuman , postoperative care , prevalence , rat , rat model , scoring system , skin abrasion , surgical technique , abdominal cavity , animal , human , laparotomy , tissue adhesion