Effect of intra-abdominal boric acid in the experimental adhesion model; [Deneysel adeyon modelinde, entraabdominal borik asidin etkisi]

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dc.contributor.authorKabalar R.B.
dc.contributor.authorTutcu Şahin S.
dc.contributor.authorAyhan S.
dc.date.accessioned2024-07-22T08:01:28Z
dc.date.available2024-07-22T08:01:28Z
dc.date.issued2024
dc.description.abstractBACKGROUND: The continuous advancement in medical and surgical techniques has led to a rise in the frequency of abdominal operations, subsequently increasing the incidence of intra-abdominal adhesions. Over 90% of laparotomies result in postoperative intra-abdominal adhesions. This study investigates the effect of a 5% boric acid solution on the development of intra-abdominal adhesions in rats, using an adhesion model. METHODS: This study was conducted with two groups: a control group, in which the adhesion model was applied without any treatment, and a boric acid group, which was treated with a 5% boric acid solution. Each group comprised 16 rats. On the 14th postoperative day, the rats were sacrificed, re-explored, and the developed adhesions were evaluated both macroscopically and microscopically. The data from macroscopic and microscopic scoring were analyzed using the Mann-Whitney U test in the IBM Statistical Package for the Social Sciences (SPSS) Statistics 24 program. A p-value of less than 0.05 was considered statistically significant. This research was supported by the Manisa Celal Bayar University Scientific Research Projects Commission. RESULTS: A statistically significant difference was observed between the boric acid-treated group and the control group, with the boric acid group showing a significant decrease in adhesion development both macroscopically and microscopically (p<0.05). CONCLUSION: In the future, boron could play a significant role in reducing and preventing intra-abdominal adhesions after surgery. This investigation could pave the way for further research into the mechanism by which boric acid prevents the development of intra-abdominal adhesions. Moreover, it is imperative to explore the potential side effects of intra-abdominal boron application at the optimum concentration of the solution. © 2024, Turkish Association of Trauma and Emergency Surgery. All rights reserved.
dc.identifier.DOI-ID10.14744/tjtes.2024.77767
dc.identifier.issn1306696X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11468
dc.language.isoEnglish
dc.publisherTurkish Association of Trauma and Emergency Surgery
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAbdominal Cavity
dc.subjectAnimals
dc.subjectBoric Acids
dc.subjectBoron
dc.subjectHumans
dc.subjectLaparotomy
dc.subjectRats
dc.subjectTissue Adhesions
dc.subjectboric acid
dc.subjectboron
dc.subjectketamine
dc.subjectxylazine
dc.subjectboric acid
dc.subjectabdomen
dc.subjectabdominal surgery
dc.subjectadhesion
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectdiagnostic procedure
dc.subjectexperimental adhesion model
dc.subjectfemale
dc.subjectfibrosis
dc.subjecthumidity
dc.subjectimmunohistochemistry
dc.subjectinflammation
dc.subjectintra abdominal adhesions
dc.subjectmacroscopy
dc.subjectmicroscopy
dc.subjectnonhuman
dc.subjectpostoperative care
dc.subjectprevalence
dc.subjectrat
dc.subjectrat model
dc.subjectscoring system
dc.subjectskin abrasion
dc.subjectsurgical technique
dc.subjectabdominal cavity
dc.subjectanimal
dc.subjecthuman
dc.subjectlaparotomy
dc.subjecttissue adhesion
dc.titleEffect of intra-abdominal boric acid in the experimental adhesion model; [Deneysel adeyon modelinde, entraabdominal borik asidin etkisi]
dc.typeArticle

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