Comparison of nephron-protective effects of enalapril and glp analogues (exenatide) in diabetic nephropathy
| dc.contributor.author | Çavusoglu T. | |
| dc.contributor.author | Erbas O. | |
| dc.contributor.author | Karadeniz T. | |
| dc.contributor.author | Akdemir O. | |
| dc.contributor.author | Acikgoz E. | |
| dc.contributor.author | Karadeniz M. | |
| dc.contributor.author | Tuglu M.I. | |
| dc.contributor.author | Ates U. | |
| dc.date.accessioned | 2025-04-10T11:13:02Z | |
| dc.date.available | 2025-04-10T11:13:02Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | Background: One of the major concerns is a nephropathy in diabetes, which applies many different kinds of medicines. However, required level of the treatment of renal disease has not been achieved. Aim: To investigate and compare the effect of the enalapril and the exenatide on diabetic nephropathy in rats developed diabetes by streptozosin. Material and Methods: 32 male Sprague Dawley rats were divided into 4 groups: (1) Control, (2) Diabetic (DM), (3) DM+ Enalapril, and (4) DM+ exenatide groups. Then, the animals were euthanized and their blood samples were collected by cardiac puncture for blood glucose; blood urea nitrogen (BUN), creatinin, and nephrectomy were performed for histopathologic examination, and urine samples were taken on stick for proteinuria. Results: Administration of the enalapril or the exenatide in diabetic rats resulted in a significant reduction both fibronectin, induced nitric oxide synthase (i-NOS) expression in glomerular area and urine protein levels. It was shown that both of enalapril and exenatide protected the renal glomerulus more than diabetic group in the nephropathy histopathologically. Conclusion: The beneficial effects of enalapril and exenatide which reduces fibronectin, i-NOS expression and urine protein levels or increases recovery of glomerules, might be used for preventing the harmful effects of diabetic nephropathy. © 2014 Georg Thieme Verlag KG Stuttgart New York. | |
| dc.identifier.DOI-ID | 10.1055/s-0034-1372584 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/49741 | |
| dc.publisher | Georg Thieme Verlag | |
| dc.title | Comparison of nephron-protective effects of enalapril and glp analogues (exenatide) in diabetic nephropathy | |
| dc.type | Article |