N-acetylcysteine ameliorates nitrosative stress on radiation-inducible damage in rat liver

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dc.contributor.authorKilciksiz S.
dc.contributor.authorDemirel C.
dc.contributor.authorAyhan S.E.
dc.contributor.authorErdal N.
dc.contributor.authorGurgul S.
dc.contributor.authorTamer L.
dc.contributor.authorAyaz L.
dc.date.accessioned2024-07-22T08:20:32Z
dc.date.available2024-07-22T08:20:32Z
dc.date.issued2011
dc.description.abstractPurpose: The present study was designed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) on radiation-induced nitrosative stress caused by gamma irradiation (single dose, 6 Gy) in rat liver. Methods: The rats (n=40) were divided randomly and equally into 4 groups: Control (C), Radiation (R), R+NAC (received irradiation and 1,000 mg/kg of NAC) and R+WR-2721 (received irradiation and 200 mg/kg of WR-2721). Liver tissue of each animal was harvested and utilized for 3-nitrotyrosine (3-NT) detection using high-performance liquid chromatography-ultraviolet (HPLC-UV) system. Results: In the R rats, 3-NT levels significantly increased when compared to those of the C rats (p<0.05). There were no significant differences in the 3-NT levels among R+NAC and R+WR-2721 rats. Histologically examined liver tissue samples showed no obvious differences. Conclusion: The present study suggests that irradiation has a negative effect on the cellular proteins by enhancing 3-NT formation. The prophylactic use of NAC seems to reduce the nitrosative damage during radiotherapy. © 2011 Zerbinis Medical Publications.
dc.identifier.issn11070625
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18190
dc.language.isoEnglish
dc.subjectAcetylcysteine
dc.subjectAmifostine
dc.subjectAnimals
dc.subjectFemale
dc.subjectLiver
dc.subjectNitric Oxide
dc.subjectRadiation-Protective Agents
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTyrosine
dc.subject3 nitrotyrosine
dc.subjectacetylcysteine
dc.subjectamifostine
dc.subjecttyrosine
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectgamma irradiation
dc.subjecthigh performance liquid chromatography
dc.subjectliver cell
dc.subjectliver histology
dc.subjectliver injury
dc.subjectnitrosative stress
dc.subjectnonhuman
dc.subjectradiation dose
dc.subjectradiation protection
dc.subjectrat
dc.subjecttreatment outcome
dc.titleN-acetylcysteine ameliorates nitrosative stress on radiation-inducible damage in rat liver
dc.typeArticle

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