The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma

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dc.contributor.authorKasap E.
dc.contributor.authorGerceker E.
dc.contributor.authorBoyacıoglu S.Ö.
dc.contributor.authorYuceyar H.
dc.contributor.authorYıldırm H.
dc.contributor.authorAyhan S.
dc.contributor.authorKorkmaz M.
dc.date.accessioned2024-07-22T08:12:04Z
dc.date.available2024-07-22T08:12:04Z
dc.date.issued2016
dc.description.abstractColorectal adenomatous polyp (CRAP) is a major risk factor for the development of sporadic colorectal cancer (CRC). Histone modifications are one of the epigenetic mechanisms that may have key roles in the carcinogenesis of CRC. The objective of the present study is to investigate the alternations in the defined histone modification gene expression profiles in patients with CRAP and CRC. Histone modification enzyme key gene expressions of the CRC, CRAP, and control groups were evaluated and compared using the reverse transcription PCR (RT-PCR) array method. Gene expression analysis was performed in the CRAP group after dividing the patients into subgroups according to the polyp diameter, pathological results, and morphological parameters which are risk factors for developing CRC in patients with CRAP. PAK1, NEK6, AURKA, AURKB, HDAC1, and HDAC7 were significantly more overexpressed in CRC subjects compared to the controls (p < 0.05). PAK1, NEK6, AURKA, AURKB, and HDAC1 were significantly more overexpressed in the CRAP group compared to the controls (p < 0.005). There were no significant differences between the CRAP and CRC groups with regards to PAK1, NEK6, AURKA, or AURKB gene overexpression. PAK1, NEK6, AURKA, and AURKB were significantly in correlation with the polyp diameter as they were more overexpressed in polyps with larger diameters. In conclusion, overexpressions of NEK6, AURKA, AURKB, and PAK1 genes can be used as predictive markers to decide the colonoscopic surveillance intervals after the polypectomy procedure especially in polyps with larger diameters. © 2015, International Society of Oncology and BioMarkers (ISOBM).
dc.identifier.DOI-ID10.1007/s13277-015-4131-6
dc.identifier.issn10104283
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15885
dc.language.isoEnglish
dc.publisherSpringer Science and Business Media B.V.
dc.subjectAdenocarcinoma
dc.subjectAdenomatous Polyposis Coli
dc.subjectAdult
dc.subjectAged
dc.subjectAurora Kinase A
dc.subjectAurora Kinase B
dc.subjectColorectal Neoplasms
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNIMA-Related Kinases
dc.subjectp21-Activated Kinases
dc.subjectaurora A kinase
dc.subjectaurora B kinase
dc.subjectcarcinoembryonic antigen
dc.subjecthistone deacetylase 1
dc.subjecthistone deacetylase 7
dc.subjectp21 activated kinase 1
dc.subjectaurora A kinase
dc.subjectaurora B kinase
dc.subjectNEK6 protein, human
dc.subjectNIMA related kinase
dc.subjectp21 activated kinase
dc.subjectPAK1 protein, human
dc.subjectadenomatous colorectal polyp
dc.subjectadult
dc.subjectArticle
dc.subjectAURKA gene
dc.subjectAURKB gene
dc.subjectcancer growth
dc.subjectcancer risk
dc.subjectcancer staging
dc.subjectcolorectal carcinoma
dc.subjectcolorectal polyp
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgene
dc.subjectgene expression profiling
dc.subjectgene overexpression
dc.subjectgeneral aspects of disease
dc.subjectgenetic association
dc.subjectHDAC1 gene
dc.subjectHDAC7 gene
dc.subjecthigh risk population
dc.subjecthistone modification
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmorphology
dc.subjectNEK6 gene
dc.subjectPAK1 gene
dc.subjectpathophysiology
dc.subjectpriority journal
dc.subjectreverse transcription polymerase chain reaction
dc.subjecttumor localization
dc.subjectadenocarcinoma
dc.subjectaged
dc.subjectcolon polyposis
dc.subjectcolorectal tumor
dc.subjectgenetics
dc.subjectpathology
dc.subjectphysiology
dc.titleThe potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma
dc.typeArticle

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