Changed Bcl:Bax ratio in endometrium of patients with unexplained infertility
| dc.contributor.author | Vatansever, HS | |
| dc.contributor.author | Lacin, S | |
| dc.contributor.author | Ozbilgin, MK | |
| dc.date.accessioned | 2024-07-18T11:54:25Z | |
| dc.date.available | 2024-07-18T11:54:25Z | |
| dc.description.abstract | Apoptosis has been shown to be an important regulator of endometrial function during the menstrual cycle and implantation. Recently, some possible implantation defects were identified in patients with unexplained infertility. In this study, we investigated the role of spontaneous apoptosis, which is regulated by death regulatory genes, such as Bc1-2, Bax, p53, and isoenzymes of nitric oxide synthases; eNOS and iNOS during the implantation window in women with unexplained infertility. Endometrial samples were evaluated from fertile (n = 15) and unexplained-infertile women (n = 15) during post-ovulatory 7th or 8th day of their menstrual, cycles. Apoptotic cells were detected using the dUTP nick-end labelling assay and Bcl-2, Bax, p53, iNOS and eNOS were assessed immunohistochemically. Reduced apoptotic cells, weak immunoreactivity of p53 and strong immunoreactivity of Bcl-2 were observed in the unexplained-infertile group compared with the fertile group (p < 0.001). Bax intensity was similar in both groups. White weak iNOS immunoreactivity was detected in both groups, moderately increased eNOS immunoreactivity was observed in infertile cases. Spontaneous apoptosis is reduced in the endometrium of unexplained-infertile women, and is associated with the changed Bcl-2:Bax ratio. This finding may be a contributing factor to defective implantation causing infertility in this group of patients. (c) 2005 Elsevier GmbH. All rights reserved. | |
| dc.identifier.issn | 0065-1281 | |
| dc.identifier.other | 1618-0372 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/6355 | |
| dc.language.iso | English | |
| dc.publisher | ELSEVIER GMBH, URBAN & FISCHER VERLAG | |
| dc.subject | INDUCIBLE NITRIC-OXIDE | |
| dc.subject | INHIBITORY FACTOR LIF | |
| dc.subject | CELL-DEATH | |
| dc.subject | IMPLANTATION WINDOW | |
| dc.subject | APOPTOSIS | |
| dc.subject | EXPRESSION | |
| dc.subject | SYNTHASE | |
| dc.subject | PROTEINS | |
| dc.subject | REPRODUCTION | |
| dc.subject | REGULATORS | |
| dc.title | Changed Bcl:Bax ratio in endometrium of patients with unexplained infertility | |
| dc.type | Article |