IL-2R, IL-6 and IL-8 levels in Behçet's disease; [Behçet hastaliǧinda IL-2R, IL-6 ve IL-8 levels]
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2010
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Abstract
Background and Design: Immunological factors are considered to have an important role in the multifactorial ethiopathogenesis of Behçet's disease (BD). Especially, Th1 cells function by expressing proinflammatory cytokines and neutrophilattracting chemokines. Levels of IL-2R, IL-6 and IL-8 were evaluated in patients with BD in this study. Material and Method: Sixty-six patients with BD (36 with inactive and 30 with active) composed the study group and 22 subjects - the control group. Cytokine analyses were done with ELISA method by using commercial kits. ESR and CRP levels were also measured. Results: IL-2R, IL-6 and IL-8 levels in all patients, including the inactive ones, were not different from those in controls. CRP and ESR levels in patients were higher than in controls. IL-8 and CRP levels were increased in patient with active BD (p<0.05) when compared to those with inactive BD. Conclusion: Our study demonstrated elevated levels of serum IL-8, a chemokine activating monunuclear cells and neutrophils, in patients with active BD. IL-8 may be considered as an activity marker for BD.