IL-2R, IL-6 and IL-8 levels in Behçet's disease; [Behçet hastaliǧinda IL-2R, IL-6 ve IL-8 levels]

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dc.contributor.authorInanir I.
dc.contributor.authorOnur E.
dc.contributor.authorPirildar T.
dc.contributor.authorGündüz K.
dc.contributor.authorVar A.
dc.date.accessioned2024-07-22T08:20:36Z
dc.date.available2024-07-22T08:20:36Z
dc.date.issued2010
dc.description.abstractBackground and Design: Immunological factors are considered to have an important role in the multifactorial ethiopathogenesis of Behçet's disease (BD). Especially, Th1 cells function by expressing proinflammatory cytokines and neutrophilattracting chemokines. Levels of IL-2R, IL-6 and IL-8 were evaluated in patients with BD in this study. Material and Method: Sixty-six patients with BD (36 with inactive and 30 with active) composed the study group and 22 subjects - the control group. Cytokine analyses were done with ELISA method by using commercial kits. ESR and CRP levels were also measured. Results: IL-2R, IL-6 and IL-8 levels in all patients, including the inactive ones, were not different from those in controls. CRP and ESR levels in patients were higher than in controls. IL-8 and CRP levels were increased in patient with active BD (p<0.05) when compared to those with inactive BD. Conclusion: Our study demonstrated elevated levels of serum IL-8, a chemokine activating monunuclear cells and neutrophils, in patients with active BD. IL-8 may be considered as an activity marker for BD.
dc.identifier.DOI-ID10.4274/turkderm.44.213
dc.identifier.issn1019214X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18241
dc.language.isoTurkish
dc.subjectC reactive protein
dc.subjectcytokine
dc.subjectinterleukin 2 receptor
dc.subjectinterleukin 6
dc.subjectinterleukin 8
dc.subjectarticle
dc.subjectBehcet disease
dc.subjectcell function
dc.subjectenzyme linked immunosorbent assay
dc.subjecterythrocyte sedimentation rate
dc.subjecthuman
dc.subjectmononuclear cell
dc.subjectneutrophil
dc.subjectTh1 cell
dc.titleIL-2R, IL-6 and IL-8 levels in Behçet's disease; [Behçet hastaliǧinda IL-2R, IL-6 ve IL-8 levels]
dc.typeArticle

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