E-Cadherin: An Important Functional Molecule at Respiratory Barrier Between Defence and Dysfunction

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dc.contributor.authorYuksel, H
dc.contributor.authorOcalan, M
dc.contributor.authorYilmaz, O
dc.date.accessioned2024-07-18T11:48:47Z
dc.date.available2024-07-18T11:48:47Z
dc.description.abstractWhile breathing, many microorganisms, harmful environmental particles, allergens, and environmental pollutants enter the human airways. The human respiratory tract is lined with epithelial cells that act as a functional barrier to these harmful factors and provide homeostasis between external and internal environment. Intercellular epithelial junctional proteins play a role in the formation of the barrier. E-cadherin is a calcium-dependent adhesion molecule and one of the most important molecules involved in intercellular epithelial barier formation. E-cadherin is not only physical barrier element but also regulates cell proliferation, differentiation and the immune response to environmental noxious agents through various transcription factors. In this study, we aimed to review the role of E-cadherin in the formation of airway epithelial barier, its status as a result of exposure to various environmental triggers, and respiratory diseases associated with its dysfunction. Moreover, the situations in which its abnormal activation can be noxious would be discussed.
dc.identifier.other1664-042X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3519
dc.language.isoEnglish
dc.publisherFRONTIERS MEDIA SA
dc.subjectAIRWAY EPITHELIAL BARRIER
dc.subjectNF-KAPPA-B
dc.subjectCIGARETTE-SMOKE
dc.subjectPULMONARY-FIBROSIS
dc.subjectMESENCHYMAL TRANSITION
dc.subjectTIGHT JUNCTIONS
dc.subjectCELL-ADHESION
dc.subjectPARTICULATE MATTER
dc.subjectOXIDATIVE STRESS
dc.subjectASTHMA
dc.titleE-Cadherin: An Important Functional Molecule at Respiratory Barrier Between Defence and Dysfunction
dc.typeReview

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