Muscle-Specific PPARβ/δ Agonism May Provide Synergistic Benefits with Life Style Modifications

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dc.contributor.authorErol, A
dc.date.accessioned2024-07-18T11:53:44Z
dc.date.available2024-07-18T11:53:44Z
dc.description.abstractPeroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) has emerged as a powerful metabolic regulator in diverse tissues including fat, skeletal muscle, and the heart. It is now established that activation of PPAR beta/delta promotes fatty acid oxidation in several tissues, such as skeletal muscle and adipose tissue. In muscle, PPAR beta/delta appears to act as a central regulator of fatty acid catabolism. PPAR beta/delta contents are increased in muscle during physiological situations such as physical exercise or long-term fasting, characterized by increased fatty acid oxidation. Targeted expression of an activated form of PPAR beta/delta in skeletal muscle induces a switch to form increased numbers of type I muscle fibers resembling the fiber type transition by endurance training. Activation of PPAR beta/delta also enhances mitochondrial capacity and fat oxidation in the skeletal muscle that resembles the effect of regular exercise. Therefore, it is hypothesized that muscle-specific PPAR beta/delta agonists could be a key strategy to support the poor cardiorespiratory fitness associated with metabolic disorders. Copyright (C) 2007 Adnan Erol.
dc.identifier.issn1687-4757
dc.identifier.other1687-4765
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/5834
dc.language.isoEnglish
dc.publisherHINDAWI LTD
dc.subjectACTIVATED-RECEPTOR-DELTA
dc.subjectOXIDATIVE ENZYME-ACTIVITY
dc.subjectSKELETAL-MUSCLE
dc.subjectFIBER-TYPE
dc.subjectINSULIN-RESISTANCE
dc.subjectGENE-EXPRESSION
dc.subjectEXERCISE
dc.subjectALPHA
dc.subjectGAMMA
dc.subjectBETA
dc.titleMuscle-Specific PPARβ/δ Agonism May Provide Synergistic Benefits with Life Style Modifications
dc.typeReview

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