Fragmented QRS is a marker of mortality in patients with severe COVID-19: A retrospective observational study

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dc.contributor.authorİbrahim Halil ÖZDEMİR
dc.contributor.authorBülent ÖZLEK
dc.contributor.authorMehmet Burak ÖZEN
dc.contributor.authorRamazan GÜNDÜZ
dc.contributor.authorNurullah ÇETİN
dc.contributor.authorEda ÖZLEK
dc.contributor.authorBekir Serhat YİLDİZ
dc.contributor.authorHakan TIKIZ
dc.date.accessioned2024-07-24T09:14:32Z
dc.date.available2024-07-24T09:14:32Z
dc.date.issued2021
dc.description.abstractObjective: In this study, we aimed to investigate the association of fragmented QRS (f-QRS) with in-hospital death in patients with severe novel coronavirus disease 2019 (COVID-19). Methods: This was a retrospective and observational study. A total of 201 consecutive patients with severe COVID-19 were enrolled. Demographic data, laboratory parameters, medications, electrocardiographic (ECG) findings, and clinical outcomes were recorded. Patients with and without f-QRS were compared, and predictors of all-cause in-hospital mortality were analyzed. Results: A total of 135 patients without f-QRS (mean age of 64 years, 43% women) and 66 patients with f-QRS (mean age of 66 years, 39% women) were included. C-reactive protein (CRP), D-dimer, troponin I, ferritin levels, and CRP to albumin ratio were significantly higher in patients with f-QRS. The need for invasive mechanical ventilation (63.6% vs. 41.5%, p=0.003) and all-cause in-hospital mortality [54.5% vs. 28.9%, log rank p=0.001, relative risk 1.88, 95% confidence interval (CI) 1.16–4.78] were significantly higher in patients with f-QRS. A number value of f-QRS leads ≥2 yields sensitivity and specificity (85.3% and 86.7%, respectively) for predicting in-hospital all-cause mortality. Multivariable analysis showed that f-QRS (odds ratio: 1.041, 95% Cl: 1.021–1.192, p=0.040) were independently associated with in-hospital death. Conclusion: This study revealed that the presence of f-QRS in ECG is associated with higher in-hospital all-cause mortality in patients with severe COVID-19. f-QRS is an easily applicable simple indicator to predict the risk of death in these patients.
dc.identifier.DOI-ID10.5152/AnatolJCardiol.2021.62
dc.identifier.issn2149-2263
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/26147
dc.language.isoeng
dc.titleFragmented QRS is a marker of mortality in patients with severe COVID-19: A retrospective observational study
dc.typeAraştırma Makalesi

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