Investigation of therapeutic efficiency of phenytoin (PHT) labeled with radioactive 131I in the cancer cell lines

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dc.contributor.authorUzaras, C
dc.contributor.authorAvcibasi, U
dc.contributor.authorDemiroglu, H
dc.contributor.authorMedine, EI
dc.contributor.authorKilçar, AY
dc.contributor.authorMüftüler, FZB
dc.contributor.authorÜnak, P
dc.date.accessioned2024-07-18T12:00:41Z
dc.date.available2024-07-18T12:00:41Z
dc.description.abstractThe aim of this study is to determine the incorporations of PHT radiolabeled with I-131 (I-131-PHT) on U-87 MG, Daoy and A549 cancerous cell lines. For this, cold and radio-labeling studies were carried out. The radio-labeling yield of I-131-PHT was obtained about 95 %. Subsequently, cell culture studies were carried out and radio-labeling yields of I-131, I-131-PHT on U-87 MG, Daoy and A549 cancerous cells were investigated. Cell culture studies demonstrated that the incorporation values of (IPHT)-I-131 on the three cell lines decreased with increasing radioactivity. Consequently, I-131-PHT may be a good radiopharmaceutical for targeting radionuclide therapy of Central Nervous System Tumors.
dc.identifier.issn0236-5731
dc.identifier.other1588-2780
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/7871
dc.language.isoEnglish
dc.publisherSPRINGER
dc.subjectBLEOMYCIN-GLUCURONIDE
dc.subjectBIODISTRIBUTION
dc.titleInvestigation of therapeutic efficiency of phenytoin (PHT) labeled with radioactive 131I in the cancer cell lines
dc.typeArticle

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