Correlation of Liver Enzyme Levels and Insulin Resistance in Patients with Non‐Alcoholic Steatosis
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Date
2019
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Abstract
Objectives: To compare non‐alcoholic steatosis patients according to liver enzyme levels, and toestablish whether glucose metabolism and insulin resistance differ with liver enzyme levels.Materials and Methods: Patients with non‐alcoholic steatosis aged between 18‐65 years were includedin this study. The patients were divided into two groups as steatotic patients with normal liver enzymes(NLE), and those with increased liver enzymes (ILE). The groups were compared as for parameters ofglucose metabolism, and insulin resistance.Results: A total of 66 steatotic patients (40 NLE, and 26 ILE) were included in our study. Mean insulinvalues in the steatotic NLE, and ILE groups were 12.92±5.61, and 16.22±5.43 μU/mL respectively(p=0.012). Insulin resistance was detected in 23 (60.50%) patients in the steatotic NLE, and in 22 (88%)patients in the steatotic ILE groups (p=0.018). Metabolic syndrome was detected in 31 (77.50%) patientsin the steatotic NLE, and in 15 (57.70%) patients in the steatotic ILE groups (p=0.058).Conclusion: In conclusion, we have concluded that the steatotic group with ILE had higher insulinresistance. These patients should be meticulously taken into consideration as for drug treatments whichwill especially decrease insulin resistance, increase both weight loss, and sensitivity to insulin resistance.Liver biopsy still retains its essential place in definitive differential diagnosis