Predictors of renal and patient outcomes in anti-neutrophilcytoplasmic antibody-associated vasculitis:Our single-center, tertiary care experience
| dc.contributor.author | Özgül SOYSAL GÜNDÜZ | |
| dc.contributor.author | Aysun TORAMAN | |
| dc.date.accessioned | 2024-07-24T09:14:35Z | |
| dc.date.available | 2024-07-24T09:14:35Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Objectives: This study aims to assess the different predictors of renal and patient prognosis in anti-neutrophil cytoplasmic antibodies(ANCA)-associated vasculitis (AAV) patients with and without renal involvement. Patients and methods: A total of 79 patients (51 males, 28 females; mean age: 57.3±14.2 years; range, 18 to 71 years) with AAV between January2006 and November 2019 were retrospectively analyzed. Demographic and laboratory data including the complement 3 (C3) serum levels andrenal biopsy findings were extracted from the electronic and printed medical records of the hospital registry. Survival, renal survival, remission, andrelapse outcomes were analyzed. Results: A total of 35% of the patients with renal involvement progressed to end-stage renal disease (ESRD). The dialysis requirement at the time ofadmission (hazard ratio [HR]: 21.95 [2.93-164.22]; p=0.003), estimated glomerular filtration rate (eGFR) (HR: 0.97 [0.94-0.99]; p=0.024) and Five-FactorScore (FFS) ≥2 at the time of diagnosis (HR: 3.59 [1.08-11.94]; p=0.037) were the predictors of ESRD. The five-year patient survival rate was 87.1%.The only predictor of mortality was age (HR: 1.07 [1.01-1.14]; p=0.024). The patients with hypocomplementemia (22%) had a lower remission rate(p=0.049), FFS ≥2 at the time of diagnosis (p=0.026), and higher levels of hematuria (p=0.004) and proteinuria (p=0.037). The FFS ≥2 at the time ofdiagnosis was an independent predictor of relapse (HR: 8.9 [1.02-77.36]; p=0.047). Conclusion: Our study suggests that the baseline renal function and FFS ≥2 at the time of diagnosis are the major prognostic factors for progressionto ESRD in AAV patients. In addition, AAV patients with hypocomplementemia may have a lower remission rate. | |
| dc.identifier.DOI-ID | 10.46497/ArchRheumatol.2021.8687 | |
| dc.identifier.issn | 2148-5046 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/26200 | |
| dc.language.iso | eng | |
| dc.title | Predictors of renal and patient outcomes in anti-neutrophilcytoplasmic antibody-associated vasculitis:Our single-center, tertiary care experience | |
| dc.type | Diğer |