Effect of chemotherapy on pulmonary epithelial permeability in lung cancer
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Date
2000
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Abstract
The aim of this study is to investigate the effect of one-course chemotherapy on the pulmonary epithelial permeability. Eighteen patients (18 male; mean age: 59 ± 10 years) with lung cancer (11 non-small cell, 7 small cell) inhaled 40 mCi (1,480 MBq) 99mTc-diethylenetriaminepentaacetic acid (DTPA). Thirty images of 1-min duration were acquired from posterior projection. The first 7 min of the decay-corrected time activity curves were used to calculate lung clearance half-time. Clearance half-times of 99mTc-DTPA from the peripheral regions of the lungs were 42 ± 19 min before and 56 ± 34 min after chemotherapy (p = 0.009); from the central regions, clearance half-times were 112 ± 94 min before and 160 ± 125 min after chemotherapy (p = 0.005). This decrease in clearance rate might be related to decreasing mucociliary clearance rate due to the toxic effect of the chemotherapy regimen on cilia movement and/or mucus structure. 99mTc-DTPA radioaerosol study can be used to monitor the toxic effects of chemotherapy on the pulmonary epithelium and possibly on mucociliary function. (C) 2000 Elsevier Science Inc.
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Keywords
Antineoplastic Combined Chemotherapy Protocols, Blood Gas Analysis, Carcinoma, Non-Small-Cell Lung, Carcinoma, Small Cell, Cell Membrane Permeability, Cisplatin, Doxorubicin, Etoposide, Forced Expiratory Volume, Humans, Ifosfamide, Lung, Lung Neoplasms, Male, Metabolic Clearance Rate, Middle Aged, Mitomycin, Mucociliary Clearance, Respiratory Mucosa, Technetium Tc 99m Pentetate, Vital Capacity, antineoplastic agent, cisplatin, doxorubicin, etoposide, ifosfamide, mitomycin, pentetate technetium tc 99m, adult, aged, article, bronchus mucus, cancer chemotherapy, clinical article, drug cytotoxicity, half life time, human, lung alveolus epithelium, lung cancer, lung clearance, lung scintiscanning, male, membrane permeability, mucociliary clearance, mucociliary transport