Effect of chemotherapy on pulmonary epithelial permeability in lung cancer

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dc.contributor.authorSayit E.
dc.contributor.authorAktoǧu S.
dc.contributor.authorErtay T.
dc.contributor.authorÇapa G.
dc.contributor.authorErkmen G.
dc.contributor.authorÖzbilek E.
dc.contributor.authorBüyükşirin M.
dc.contributor.authorDurak H.
dc.date.accessioned2024-07-22T08:25:42Z
dc.date.available2024-07-22T08:25:42Z
dc.date.issued2000
dc.description.abstractThe aim of this study is to investigate the effect of one-course chemotherapy on the pulmonary epithelial permeability. Eighteen patients (18 male; mean age: 59 ± 10 years) with lung cancer (11 non-small cell, 7 small cell) inhaled 40 mCi (1,480 MBq) 99mTc-diethylenetriaminepentaacetic acid (DTPA). Thirty images of 1-min duration were acquired from posterior projection. The first 7 min of the decay-corrected time activity curves were used to calculate lung clearance half-time. Clearance half-times of 99mTc-DTPA from the peripheral regions of the lungs were 42 ± 19 min before and 56 ± 34 min after chemotherapy (p = 0.009); from the central regions, clearance half-times were 112 ± 94 min before and 160 ± 125 min after chemotherapy (p = 0.005). This decrease in clearance rate might be related to decreasing mucociliary clearance rate due to the toxic effect of the chemotherapy regimen on cilia movement and/or mucus structure. 99mTc-DTPA radioaerosol study can be used to monitor the toxic effects of chemotherapy on the pulmonary epithelium and possibly on mucociliary function. (C) 2000 Elsevier Science Inc.
dc.identifier.DOI-ID10.1016/S0969-8051(00)00133-5
dc.identifier.issn09698051
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20555
dc.language.isoEnglish
dc.subjectAntineoplastic Combined Chemotherapy Protocols
dc.subjectBlood Gas Analysis
dc.subjectCarcinoma, Non-Small-Cell Lung
dc.subjectCarcinoma, Small Cell
dc.subjectCell Membrane Permeability
dc.subjectCisplatin
dc.subjectDoxorubicin
dc.subjectEtoposide
dc.subjectForced Expiratory Volume
dc.subjectHumans
dc.subjectIfosfamide
dc.subjectLung
dc.subjectLung Neoplasms
dc.subjectMale
dc.subjectMetabolic Clearance Rate
dc.subjectMiddle Aged
dc.subjectMitomycin
dc.subjectMucociliary Clearance
dc.subjectRespiratory Mucosa
dc.subjectTechnetium Tc 99m Pentetate
dc.subjectVital Capacity
dc.subjectantineoplastic agent
dc.subjectcisplatin
dc.subjectdoxorubicin
dc.subjectetoposide
dc.subjectifosfamide
dc.subjectmitomycin
dc.subjectpentetate technetium tc 99m
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectbronchus mucus
dc.subjectcancer chemotherapy
dc.subjectclinical article
dc.subjectdrug cytotoxicity
dc.subjecthalf life time
dc.subjecthuman
dc.subjectlung alveolus epithelium
dc.subjectlung cancer
dc.subjectlung clearance
dc.subjectlung scintiscanning
dc.subjectmale
dc.subjectmembrane permeability
dc.subjectmucociliary clearance
dc.subjectmucociliary transport
dc.titleEffect of chemotherapy on pulmonary epithelial permeability in lung cancer
dc.typeArticle

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