A nationwide retrospective study in Turkish children with nephrocalcinosis

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dc.contributor.authorSerra Sürmeli DÖVEN
dc.contributor.authorSebahat TÜLPAR
dc.contributor.authorFunda BAŞTUĞ
dc.contributor.authorZeynep YÜRÜK YILDIRIM
dc.contributor.authorEsra Karabağ YILMAZ
dc.contributor.authorNeslihan ÇİÇEK
dc.contributor.authorNuran KÜÇÜK
dc.contributor.authorElif ÇOMAK
dc.contributor.authorBurcu YAZICIOĞLU
dc.contributor.authorHülya NALCACIOĞLU
dc.contributor.authorAli DELİBAŞ
dc.contributor.authorBerfin UYSAL
dc.contributor.authorAyşe AĞBAŞ
dc.contributor.authorAtilla GEMİCİ
dc.contributor.authorNeslihan GÜNAY
dc.contributor.authorPelin ERTAN
dc.contributor.authorNeşe BIYIKLI
dc.contributor.authorDuygu Övünç HACIHAMDİOĞLU
dc.contributor.authorAhmet Midhat ELMACI
dc.contributor.authorYeşim Özdemir ATİKEL
dc.contributor.authorEmine Özlem Çam DELEBE
dc.contributor.authorLale SEVER
dc.contributor.authorIbrahim GOKCE
dc.contributor.authorNimet ÖNER
dc.contributor.authorSema AKMAN
dc.contributor.authorBağdagül AKSU
dc.contributor.authorBahriye ATMIŞ
dc.contributor.authorSibel YEL
dc.contributor.authorAlev YILMAZ
dc.contributor.authorBinnaz ÇELİK
dc.contributor.authorİsmail DURSUN
dc.contributor.authorHarika ALPAY
dc.date.accessioned2024-07-24T09:14:35Z
dc.date.available2024-07-24T09:14:35Z
dc.date.issued2021
dc.description.abstractBackground/aim: Nephrocalcinosis (NC) is defined as calcium deposition in the kidney parenchyma and tubules. This study aims to determine the etiology, risk factors, and follow-up results of patients with NC in Turkey. Materials and methods: Patients diagnosed with NC in the pediatric nephrology Department Units of 19 centers from all geographical regions of Turkey over a 10-year period (2010–2019) were included in the study. The medical records from the centers were reviewed and demographic data, admission complaints, medical history, systemic and genetic disorders, risk factors for NC, treatment details, and presence of NC after one-year follow-up, were recorded retrospectively. Results: The study sample included 195 patients (88 females, 107 males). The mean age at diagnosis was 39.44 ± 47.25 (0.5–208) months; 82/190 patients (43.2%) were diagnosed incidentally; 46/195 patients (23.6%) had an underlying disease; idiopathic hypercalciuria was detected in 75/195 (38.4%) patients. The most common systemic diseases were distal renal tubular acidosis in 11/46 patients (23.9%), primary hyperoxaluria in 9/46 patients (19.6%) and Bartter syndrome in 7/46 patients (15.3%). After one year of follow-up, NC resolved in 56/159 patients (35.2%) and they all did not have an underlying systemic disease. Conclusion: The most common presentation of NC was incidental. Distal renal tubular acidosis and primary hyperoxaluria were the main systemic diseases leading to NC, while hypercalciuria was the most common metabolic risk factor. Nephrocalcinosis was found to remain in most of the patients at a one-year follow-up. It may resolve particularly in patients with no underlying systemic disease.Keywords: Bartter syndrome, hypercalciuria, nephrocalcinosis, renal tubular acidosis
dc.identifier.DOI-ID10.3906/sag-2103-347
dc.identifier.issn1300-0144
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/26199
dc.language.isoeng
dc.titleA nationwide retrospective study in Turkish children with nephrocalcinosis
dc.typeAraştırma Makalesi

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