The effects of melatonin and thymoquinone on doxorubicin-induced cardiotoxicity in rats

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dc.contributor.authorPehlivan, DY
dc.contributor.authorDurdagi, G
dc.contributor.authorOyar, EO
dc.contributor.authorAkyol, S
dc.contributor.authorOzbek, M
dc.date.accessioned2024-07-18T12:00:35Z
dc.date.available2024-07-18T12:00:35Z
dc.description.abstractOBJECTIVES: This study aims to investigate the protective effects of thymoquinone and melatonin on the heart against doxorubicin-induced cardiotoxicity in rats. BACKGROUND: Melatonin and thymoquinone may play an important role in cardiotoxicity. METHODS: The subjects were divided into four groups: Control (physiological serum on 5th day), Doxorubicin (DXR), Doxorubicin+Melatonin (DXR+MEL, 10 mg/kg melatonin, intraperitoneally), and Doxorubicin+Thymoquinone (DXR+TQ, 50 mg/kg thymoquinone, orally). On the 5th day of the experiment, all groups were injected with 45 mg/kg DXR into the tail vein. On the 8th day of the experiment, ECG recordings were performed under anaesthesia. RESULTS: Thymoquinone reduced the PR, QRS and QTc intervals, which were increased by DXR, while melatonin only reduced the QTc interval. Melatonin had a protective effect against the histopathological changes induced by DXR, while TQ did not demonstrate such an effect. DXR increased CK-MB, IL-6, MDA, IL-1, IL-18 levels and decreased SOD in the cardiac tissue. MEL reduced the levels of CK-MB, MDA, NO, SOD, IL-1, IL-6, IL-18. Meanwhile, TQ only reduced CK-MB, IL-1 and IL-18. CONCLUSION: Our study showed that DXR induces cardiac injury and that melatonin improves biochemical parameters and offers histological protection; while thymoquinone improves ECG parameters and causes partial recovery of biochemical parameters (Tab. 4, Fig. 2, Ref. 41). Text in PDF www.elis.sk
dc.identifier.issn0006-9248
dc.identifier.other1336-0345
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/7825
dc.language.isoEnglish
dc.publisherCOMENIUS UNIV
dc.subjectANTIOXIDANT STATUS
dc.subjectOXIDATIVE STRESS
dc.subjectSUPPLEMENTATION
dc.subjectINJURY
dc.titleThe effects of melatonin and thymoquinone on doxorubicin-induced cardiotoxicity in rats
dc.typeArticle

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