The association of apolipoprotein e polymorphism and lipid levels in children with a family history of premature coronary artery disease

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dc.contributor.authorÇiftdoǧan D.Y.
dc.contributor.authorCoskun S.
dc.contributor.authorUlman C.
dc.contributor.authorT́ykýz H.
dc.date.accessioned2024-07-22T08:19:42Z
dc.date.available2024-07-22T08:19:42Z
dc.date.issued2012
dc.description.abstractBackground: Polymorphisms in the apolipoprotein E (apoE) gene may modulate lipoprotein metabolism and influence plasma lipid levels. Thus, they have been associated with relative risk of coronary artery disease (CAD). Objective: To evaluate the association of apolipoprotein E polymorphism and lipid levels in children with family history of premature coronary artery disease. Methods: The apoE genotypes, allele frequencie,s and plasma lipid levels were analyzed in 137 children. Among these children, 70 (study group) had and 67 (control group) did not have a parental history of premature CAD Results: Total cholesterol (Tc) levels were greater in the study group (P =.04). The frequencies of ε3ε4 genotype and ε4 allele were significantly greater in the study group (P = 005 for both), Thε ε2 allele correlated negatively with Tc and low-density lipoprotein cholesterol levels, and ε4 had a positive correlation with Tc and low-density lipoprotein cholesterol levels. Conclusions: Tc levels are influenced by apoE genotypes in childhood. Also, the frequency of the ε4 allele is greater in children with family history of premature CAD. The ε4 allele may be associated with an increased risk for development of atherosclerosis by elevated levels of Tc in children with family history of CAD. The evaluation of apoE gene polymorhisms may contribute to the assessment of cardiovascular risk in children with a family history of CAD. © 2012 National Lipid Association. All rights reserved.
dc.identifier.DOI-ID10.1016/j.jacl.2011.06.017
dc.identifier.issn18764789
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17798
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAlleles
dc.subjectApolipoprotein E4
dc.subjectCase-Control Studies
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCholesterol
dc.subjectCholesterol, LDL
dc.subjectCoronary Artery Disease
dc.subjectDNA Mutational Analysis
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenetic Association Studies
dc.subjectGenotype
dc.subjectHumans
dc.subjectMale
dc.subjectPolymorphism, Genetic
dc.subjectapolipoprotein E
dc.subjectcholesterol
dc.subjectlipid
dc.subjectlow density lipoprotein
dc.subjectadolescent
dc.subjectarticle
dc.subjectatherosclerosis
dc.subjectcardiovascular risk
dc.subjectchild
dc.subjectchildhood disease
dc.subjectcholesterol blood level
dc.subjectcontrolled study
dc.subjectcoronary artery disease
dc.subjectcorrelational study
dc.subjectdisease association
dc.subjectfamily history
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetic polymorphism
dc.subjectgenetic risk
dc.subjectgenotype
dc.subjecthuman
dc.subjectlipid blood level
dc.subjectlipoprotein metabolism
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedical history
dc.subjectpremature coronary artery disease
dc.subjectpriority journal
dc.subjectschool child
dc.titleThe association of apolipoprotein e polymorphism and lipid levels in children with a family history of premature coronary artery disease
dc.typeArticle

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