The Impact of Standards on Intensive Care in Infection Control
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Abstract
Recently, a trial of early hemodynamic resuscitation to normal physiologic parameters, or early goal-directed therapy, was conducted in emergency department patients with severe sepsis/septic shock and revealed a significant mortality reduction. Early goal-directed therapy is an algorithmic approach to hemodynamic optimization and resolution of global tissue hypoxia within the first 6 hours of disease presentation. The strategy tar gets normal oxygen delivery by optimizing preload, afterload, oxygen content, and contractility to achieve a balance between tissue oxygen delivery and consumption This article will review early goal-directed therapy, its beneficial effect and some obstacles.