The Effects of Fibroblast Growth Factor-2 Blocking on Development of Chick Cervical Vertebra and Relationship with Oxidative Stress and Apoptosis

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dc.contributor.authorDuransoy, YK
dc.contributor.authorSimsek, T
dc.contributor.authorÖztürk, F
dc.contributor.authorMete, M
dc.contributor.authorTuglu, MI
dc.contributor.authorSelçuki, M
dc.date.accessioned2024-07-18T11:49:48Z
dc.date.available2024-07-18T11:49:48Z
dc.description.abstractFibroblast growth factor (FGF) plays a role in the development of bone and cartilage. FGF-2 is a member of this family and blocking of FGF-2 affects the bone development. In this study, effects of FGF-2 blocking on the formation of vertebrae in chick embryos before ossifications and orientation of cervical vertebrae were investigated with histological examinations. In this study, anti-FGF-2 was performed to chick embryos at E4th and E10th days. Samples were taken in E15th days and changes in the cervical spine were evaluated as histochemically (with hematoxylin-eosin, Alizarin red, Masson's trichrome staining) and immunohistochemically (with iNOS, eNOS and TUNEL). Also changings were evaluated by morphometric analysis. In macroscopic examination of the cervical vertebrae significant difference was not detected. But in histochemical staining, defects were observed in cartilage and ossification process. Increasing in oxidative stress was demonstrated by iNOS and eNOS. Also apoptosis which was represented by tunnel was found to be increased. FGF-2 blocking affects the ossification process in the cervical spine by inducing oxidative stress and apoptosis which results with cell death.
dc.identifier.issn1302-1664
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/4286
dc.language.isoEnglish
dc.publisherJOURNAL NEUROLOGICAL SCIENCES
dc.subjectOXIDE PROTECTS OSTEOBLASTS
dc.subjectNITRIC-OXIDE
dc.subjectBONE-DEVELOPMENT
dc.subjectEXPRESSION
dc.subjectEMBRYO
dc.subjectDIFFERENTIATION
dc.subjectPROLIFERATION
dc.subjectINSULTS
dc.subjectSYSTEM
dc.subjectACID
dc.titleThe Effects of Fibroblast Growth Factor-2 Blocking on Development of Chick Cervical Vertebra and Relationship with Oxidative Stress and Apoptosis
dc.typeArticle

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