The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain

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dc.contributor.authorGürpinar, T
dc.contributor.authorEkerbiçer, N
dc.contributor.authorUysal, N
dc.contributor.authorBarut, T
dc.contributor.authorTarakçi, F
dc.contributor.authorTuglu, MI
dc.date.accessioned2024-07-18T12:00:44Z
dc.date.available2024-07-18T12:00:44Z
dc.description.abstractOxidative stress plays an important role in the development of complications in diabetes mellitus. Antioxidant therapy has been thought to decrease oxidative stress. The objective of the present study was to explore the effects of melatonin (MLT) on oxidative stress in diabetic rat eye and brain tissue by using immunohistochemical methods. Diabetes was induced by streptozotocin, (STZ, 55 mg/kg/i.p) in adult rats. MLT was given 10 mg/kg/i.p once a day for 2 weeks beginning from the sixth week. Six weeks later, rats were divided into three groups: control (CR), STZ-induced diabetic (STZ), and STZ-induced diabetic group received melatonin (STZ+MLT). Although no significant difference was observed with respect to antioxidant status, NOS activity tended to be higher in the untreated diabetic rats than in the treated rats. It was observed that MLT treatment improved the histopathological changes including apoptosis and oxidative stress in brain and eye in diabetic rat.
dc.identifier.issn1537-744X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/7936
dc.language.isoEnglish
dc.publisherHINDAWI PUBLISHING CORPORATION
dc.subjectNITRIC-OXIDE SYNTHASE
dc.subjectPHYSIOLOGICAL CONCENTRATIONS
dc.subjectCEREBRAL-ISCHEMIA
dc.subjectRATS
dc.subjectSTREPTOZOTOCIN
dc.subjectACTIVATION
dc.subjectPANCREAS
dc.subjectINHIBIT
dc.subjectINJURY
dc.subjectDEATH
dc.titleThe Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain
dc.typeArticle

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