Synthesis, characterization, and 5-fluorouracil release behavior of superparamagnetic ?-Fe2O3/ZnO hetero-nanostructures for biomedical applications
| dc.contributor.author | Saatci, M | |
| dc.contributor.author | Deliormanli, AM | |
| dc.date.accessioned | 2024-07-18T11:46:49Z | |
| dc.date.available | 2024-07-18T11:46:49Z | |
| dc.description.abstract | In this study, superparamagnetic maghemite (gamma-Fe2O3) nanosystems in the form of nanoparticles were fabricated through the co-precipitation method at different processing conditions. Additionally, novel gamma-Fe2O3/ZnO het-erostructures were fabricated using zinc acetate as the zinc source and polyvinyl pyrrolidone (PVP), and eth-ylenediaminetetraacetic acid (EDTA) as the capping agents. The results revealed that the size of the crystallites of the prepared maghemite nanopowders was between 6 nm and 7.8 nm depending on the synthesis temperature. The saturation magnetization value of maghemite nanopowders synthesized at 90 degrees C was measured to be 51.58 emu/g without hysteresis with negligible coercivity. FTIR analysis results proved the presence of ZnO in the maghemite core-based nanosystem. The formation of a ZnO coating using zinc acetate in the presence of PVP and EDTA as a capping agent caused a decrease in magnetization value to 12 emu/g. A ZnO coating provided better dispersion of maghemite nanoparticles and it also affected the drug (5-FU) delivery behavior. ZnO-coated nanoparticles showed prolonged and sustained drug release additionally, they continue to release the drug after 410 h. The 5-FU release kinetics of the prepared heterogeneous nanostructures fitted well with the Korsmeyer-Peppas model. | |
| dc.identifier.issn | 0272-8842 | |
| dc.identifier.other | 1873-3956 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3045 | |
| dc.language.iso | English | |
| dc.publisher | ELSEVIER SCI LTD | |
| dc.subject | IRON-OXIDE NANOPARTICLES | |
| dc.subject | MAGHEMITE GAMMA-FE2O3 | |
| dc.subject | FABRICATION | |
| dc.subject | MAGNETITE | |
| dc.subject | DRUG | |
| dc.title | Synthesis, characterization, and 5-fluorouracil release behavior of superparamagnetic ?-Fe2O3/ZnO hetero-nanostructures for biomedical applications | |
| dc.type | Article |