Gastric emptying of solids and its relationship with microalbuminuria in children and adolescents with type 1 diabetes mellitus
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2013
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Abstract
Background: The aims of the present study were to determine the frequency of delayed gastric emptying in children and adolescents with type 1 diabetes mellitus (T1DM) and to investigate the relationship between gastric emptying rate and other contributing factors (e.g. serum HbA1c, duration of diabetes and microalbuminuria) in these patients. Methods: This was a clinical trial evaluating the rate of gastric emptying of solid meals in 33 children and adolescents with T1DM and in 26 healthy peers using a radionuclide method. Three consecutive overnight urine collections were used to calculate the albumin excretion rate. Results: There was no significant difference in the gastric half-emptying time (GE t1/2) between patients and controls (151.7±154.5 vs 109.8±60.5min, respectively; P=0.885) or the frequency of delayed gastric emptying (36.4% vs 30.8%, respectively; P=0.433). There was a moderately positive correlation between GE t1/2 and the duration of diabetes (r=0.380; P=0.029). There was no correlation between GE t1/2 and microalbumin levels in T1DM patients. In these patients, the body mass index standard deviation scores were significantly lower than in patients with normal gastric emptying (-0.13±0.87 vs 0.7±1.23, respectively; P=0.044). Conclusion: Progression of delayed gastric emptying is more likely to be related to a longer duration of diabetes than glycemic control in children and adolescents with T1DM. Patients with delayed gastric emptying are thinner compared with patients with a normal rate of gastric emptying; they may also be asymptomatic. © 2013 Wiley Publishing Asia Pty Ltd and Ruijin Hospital, Shanghai Jiaotong University School of Medicine.
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Adolescent , Albuminuria , Blood Glucose , Body Mass Index , Child , Diabetes Mellitus, Type 1 , Female , Food , Gastric Emptying , Hemoglobin A, Glycosylated , Humans , Hypoglycemic Agents , Insulin , Male , Time Factors , autonomic neuropathy , gastric emptying , microalbuminuria , type1 diabetes mellitus , glucose , hemoglobin A1c , article , body mass , clinical article , controlled study , diabetic ketoacidosis , disease duration , dyspepsia , female , glucose blood level , glycemic control , human , insulin dependent diabetes mellitus , insulin treatment , male , microalbuminuria , nausea and vomiting , priority journal , stomach emptying