Gastric emptying of solids and its relationship with microalbuminuria in children and adolescents with type 1 diabetes mellitus

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dc.contributor.authorErsoy B.
dc.contributor.authorSayit E.
dc.contributor.authorCan S.
dc.contributor.authorUrk V.
dc.contributor.authorBatok D.
dc.contributor.authorPolat M.
dc.date.accessioned2024-07-22T08:18:17Z
dc.date.available2024-07-22T08:18:17Z
dc.date.issued2013
dc.description.abstractBackground: The aims of the present study were to determine the frequency of delayed gastric emptying in children and adolescents with type 1 diabetes mellitus (T1DM) and to investigate the relationship between gastric emptying rate and other contributing factors (e.g. serum HbA1c, duration of diabetes and microalbuminuria) in these patients. Methods: This was a clinical trial evaluating the rate of gastric emptying of solid meals in 33 children and adolescents with T1DM and in 26 healthy peers using a radionuclide method. Three consecutive overnight urine collections were used to calculate the albumin excretion rate. Results: There was no significant difference in the gastric half-emptying time (GE t1/2) between patients and controls (151.7±154.5 vs 109.8±60.5min, respectively; P=0.885) or the frequency of delayed gastric emptying (36.4% vs 30.8%, respectively; P=0.433). There was a moderately positive correlation between GE t1/2 and the duration of diabetes (r=0.380; P=0.029). There was no correlation between GE t1/2 and microalbumin levels in T1DM patients. In these patients, the body mass index standard deviation scores were significantly lower than in patients with normal gastric emptying (-0.13±0.87 vs 0.7±1.23, respectively; P=0.044). Conclusion: Progression of delayed gastric emptying is more likely to be related to a longer duration of diabetes than glycemic control in children and adolescents with T1DM. Patients with delayed gastric emptying are thinner compared with patients with a normal rate of gastric emptying; they may also be asymptomatic. © 2013 Wiley Publishing Asia Pty Ltd and Ruijin Hospital, Shanghai Jiaotong University School of Medicine.
dc.identifier.DOI-ID10.1111/1753-0407.12051
dc.identifier.issn17530407
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17257
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAlbuminuria
dc.subjectBlood Glucose
dc.subjectBody Mass Index
dc.subjectChild
dc.subjectDiabetes Mellitus, Type 1
dc.subjectFemale
dc.subjectFood
dc.subjectGastric Emptying
dc.subjectHemoglobin A, Glycosylated
dc.subjectHumans
dc.subjectHypoglycemic Agents
dc.subjectInsulin
dc.subjectMale
dc.subjectTime Factors
dc.subjectautonomic neuropathy
dc.subjectgastric emptying
dc.subjectmicroalbuminuria
dc.subjecttype1 diabetes mellitus
dc.subjectglucose
dc.subjecthemoglobin A1c
dc.subjectarticle
dc.subjectbody mass
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdiabetic ketoacidosis
dc.subjectdisease duration
dc.subjectdyspepsia
dc.subjectfemale
dc.subjectglucose blood level
dc.subjectglycemic control
dc.subjecthuman
dc.subjectinsulin dependent diabetes mellitus
dc.subjectinsulin treatment
dc.subjectmale
dc.subjectmicroalbuminuria
dc.subjectnausea and vomiting
dc.subjectpriority journal
dc.subjectstomach emptying
dc.titleGastric emptying of solids and its relationship with microalbuminuria in children and adolescents with type 1 diabetes mellitus
dc.typeArticle

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