Risk factors for radiation failure in early-stage glottic carcinoma: A systematic review and meta-analysis

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dc.contributor.authorEskiizmir, G
dc.contributor.authorBaskin, Y
dc.contributor.authorYalçin, F
dc.contributor.authorEllidokuz, H
dc.contributor.authorFerris, RL
dc.date.accessioned2024-07-18T12:03:51Z
dc.date.available2024-07-18T12:03:51Z
dc.description.abstractBackground: Radiotherapy is one of the main treatment modalities for early-stage glottic carcinoma. Unfortunately, local failure may occur in a group of cases with T1-T2 glottic carcinoma. This meta-analysis sought to determine risk factors for radiation failure in patients with early-stage glottic carcinoma. Methods: A systematic and comprehensive search was performed for related studies published between 1995 and 2014. The primary end-point was 5-year local control. Data extraction and analysis were performed using the software STATA/SE 13.1 for Windows. Results: Twenty-seven studies were eligible. A higher risk of radiation failure was demonstrated in male patients [relative risk (RR): 0.927, p < 0.001] and those with low hemoglobin level (RR: 0.891, p < 0.001) with a high agreement between studies (I-squared = 0.0%). Moreover, T2 tumors (RR: 0.795, p < 0.001), tumors with anterior commissure involvement (RR: 0.904, p < 0.001), tobacco use during/after therapy (RR: 0.824, p < 0.001), and bulky tumors (RR: 1.270, p < 0.001] or tumors bigger in size (RR: 1.332, p < 0.001]. Poorly differentiated tumors had a questionable risk of local failure, although a moderate to high interstudy heterogeneity was determined. A statistically significant contribution was not detected for age, presence of comorbidity, alcohol use or subglottic extension. Conclusion: This is the first meta-analysis which assessed the potential risk factors for radiation failure in patients with early-stage glottic carcinoma. Gender and pretreatment hemoglobin level are major influential factors associated with radiation failure in patients with early-stage glottic carcinoma. However, prospective, randomized clinical trials may permit better stratification of their relative contributions, and those who may benefit more from upfront surgery. (C) 2016 Elsevier Ltd. All rights reserved.
dc.identifier.issn1368-8375
dc.identifier.other1879-0593
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9382
dc.language.isoEnglish
dc.publisherELSEVIER
dc.subjectSQUAMOUS-CELL CARCINOMA
dc.subjectINDEPENDENT PROGNOSTIC-FACTOR
dc.subjectPREDICT LOCAL-CONTROL
dc.subjectDEFINITIVE RADIOTHERAPY
dc.subjectANTERIOR COMMISSURE
dc.subjectLASER-SURGERY
dc.subjectCOMPUTED-TOMOGRAPHY
dc.subjectTOTAL LARYNGECTOMY
dc.subjectNECK-CANCER
dc.subjectPHARYNGOCUTANEOUS FISTULA
dc.titleRisk factors for radiation failure in early-stage glottic carcinoma: A systematic review and meta-analysis
dc.typeReview

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