Outcomes of high-risk breast lesions diagnosed using image-guided core needle biopsy: results from a multicenter retrospective study

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dc.contributor.authorAYSE NUR OKTAY ALFATLI
dc.contributor.authorÖZGE ASLAN
dc.contributor.authorFUSUN TASKIN
dc.contributor.authorNERMIN TUNÇBILEK
dc.contributor.authorGul Esen Icten
dc.contributor.authorPINAR BALCI
dc.contributor.authorErkin ARIBAL
dc.contributor.authorLevent Çelik
dc.contributor.authorİhsan Şebnem ÖRGÜÇ
dc.contributor.authorFigen Basaran Demirkazik
dc.contributor.authorSerap Gultekin
dc.contributor.authorAyşe Murat Aydın
dc.contributor.authorEmel DURMAZ
dc.contributor.authorSibel Kul
dc.contributor.authorFigen Binokay
dc.contributor.authorMeltem Cetin
dc.contributor.authorGanime Dilek Emlik
dc.contributor.authorMeltem Gülsün Akpınar
dc.contributor.authorNuray Voyvoda
dc.contributor.authorAhmet Veysel Polat
dc.contributor.authorIşıl Başara Akın
dc.contributor.authorSeyma Yıldız
dc.contributor.authorNecdet Poyraz
dc.contributor.authorArzu Ozsoy
dc.contributor.authorPelin Seher Oztekin
dc.contributor.authorEda ELVERİCİ
dc.contributor.authorIlkay bayrak
dc.contributor.authorTurkan Ikizceli
dc.contributor.authorFunda Dinç
dc.contributor.authorGulten SEZGIN
dc.contributor.authorGökçe Gülşen
dc.contributor.authorisil Tuncbilek
dc.contributor.authorSabiha rabia Yalçın
dc.contributor.authorGül Çolakoglu
dc.contributor.authorSERPİL AĞLAMIŞ
dc.contributor.authorravza yilmaz
dc.contributor.authorGUNAY RONA
dc.contributor.authorgamze durhan
dc.contributor.authorDavut Can Guner
dc.contributor.authorFatma Yabul
dc.contributor.authorLeman Gunbey Karabekmez
dc.contributor.authorBurçin Tutar
dc.contributor.authormuhammet göktaş
dc.contributor.authorOnur Buğdaycı
dc.contributor.authorASLI SUNER
dc.contributor.authorNecmetiin Özdemir
dc.date.accessioned2025-04-14T05:51:55Z
dc.date.available2025-04-14T05:51:55Z
dc.date.issued2023
dc.description.abstractPURPOSE The clinical management of high-risk lesions using image-guided biopsy is challenging. This study aimed to evaluate the rates at which such lesions were upgraded to malignancy and identify possible predictive factors for upgrading high-risk lesions. METHODS This retrospective multicenter analysis included 1.343 patients diagnosed with high-risk lesions using an image-guided core needle or vacuum-assisted biopsy (VAB). Only patients managed using an excisional biopsy or with at least one year of documented radiological follow-up were included. For each, the Breast Imaging Reporting and Data System (BI-RADS) category, number of samples, needle thickness, and lesion size were correlated with malignancy upgrade rates in different histologic subtypes. Pearson’s chi-squared test, the Fisher–Freeman–Halton test, and Fisher’s exact test were used for the sta- tistical analyses. RESULTS The overall upgrade rate was 20.6%, with the highest rates in the subtypes of intraductal papilloma (IP) with atypia (44.7%; 55/123), followed by atypical ductal hyperplasia (ADH) (38.4%; 144/375), lobular neoplasia (LN) (12.7%; 7/55), papilloma without atypia (9.4%; 58/611), flat epithelial atypia (FEA) (8.7%; 10/114), and radial scars (RSs) (4.6%; 3/65). There was a significant relationship between the upgrade rate and BI-RADS category, number of samples, and lesion size Lesion size was the most predictive factor for an upgrade in all subtypes. CONCLUSION ADH and atypical IP showed considerable upgrade rates to malignancy, requiring surgical excision. The LN, IP without atypia, pure FEA, and RS subtypes showed lower malignancy rates when the BI-RADS category was lower and in smaller lesions that had been adequately sampled using VAB. After being discussed in a multidisciplinary meeting, these cases could be managed with follow-up instead of excision.
dc.identifier.DOI-ID10.4274/dir.2022.221790
dc.identifier.urihttp://hdl.handle.net/20.500.14701/54932
dc.language.isoİngilizce
dc.subjectMikroskopi
dc.subjectGörüntüleme Bilimi ve Fotoğraf Teknolojisi
dc.subjectOnkoloji
dc.subjectGöz Hastalıkları
dc.titleOutcomes of high-risk breast lesions diagnosed using image-guided core needle biopsy: results from a multicenter retrospective study

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