Determination of Vitamin D Metabolism and Bone Strength by Quantitative Ultrasound in Term Newborns
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Date
2018
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Abstract
INTRODUCTION: Insufficient intake of vitamin D negativelyeffects bone mineralization and turnover. Changes in mothers’bone turnover during pregnancy effects bone mineralcomposition of the fetus. The aim of this study was to evaluatethe factors, biochemical markers and bone structure assessedby quantitative ultrasonography effecting vitamin Dmetabolism.METHODS: Ninety term newborn and their mothers includedin the study. Serum levels of Ca, P, alkaline phosphatase(ALP), bone ALP (BALP), 1,25(OH)2D, 25(OH)D, parathyroidhormone (PTH), and osteocalcine levels were analyzed fromthe serums of mothers. Quantitative ultrasound from the tibialbone was performed for all infants during the first 96 hoursRESULTS: Mean values for 25(OH)D and 1,25(OH)2D werewithin normal ranges in mothers. Mean blood Ca levels of thenewborns was 10.1 ±0.6 mg/dl, and mean P levels of thenewborns was 6.2±1 mg/dl. Serum 25(OH)D values were highin mother who used vitamin D supplementation (P=0.02), PTHvalues were high and osteocalcine values were low in motherswho did not used vitamin D supplementation (P=0.02 andP=0.03, respectively). PTH values were low in newbornswhose mothers did not received vitamin D supplementation(P=0.004). 25(OH)D values were high in mothers whoreceived Ca supplementation (P=0.009). SOS values ofnewborns were 3127±107 (range, 2900-3389), and mean Zscores were 0.3±0.7 (range, -1.4 - 2.6).DISCUSSION AND CONCLUSION: Significant correlationwas observed between the SOS scores and Ca and ALP valuesof the newborns. Assessment of the structure of bone withquantitative ultrasound is a noninvasive and practical method.