CHA2DS2-VASc score and modified CHA2DS2-VASc score can predict mortality and intensive care unit hospitalization in COVID-19 patients
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2021
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Abstract
In this study, we investigated whether the CHA2DS2-VASc score could be used to estimate the need for hospitalization in the intensive care unit (ICU), the length of stay in the ICU, and mortality in patients with COVID-19. Patients admitted to Merkezefendi State Hospital because of COVID-19 diagnosis confirmed by RNA detection of virus by using polymerase chain reaction between March 24, 2020 and July 6, 2020, were screened retrospectively. The CHA2DS2-VASc and modified CHA2DS2-VASc score of all patients was calculated. Also, we received all patients’ complete biochemical markers including D-dimer, Troponin I, and c-reactive protein on admission. We enrolled 1000 patients; 791 were admitted to the general medical service and 209 to the ICU; 82 of these 209 patients died. The ROC curves of the CHA2DS2-VASc and M-CHA2DS2-VASc scores were analyzed. The cut-off values of these scores for predicting mortality were ≥ 3 (2 or under and 3). The CHA2DS2-VASc and M-CHA2DS2-VASc scores had an area under the curve value of 0.89 on the ROC. The sensitivity and specificity of the CHA2DS2-VASc scores were 81.7% and 83.8%, respectively; the sensitivity and specificity of the M-CHA2DS2-VASc scores were 85.3% and 84.1%, respectively. Multivariate logistic regression analysis showed that CHA2DS2-VASc, Troponin I, D-Dimer, and CRP were independent predictors of mortality in COVID-19 patients. Using a simple and easily available scoring system, CHA2DS2-VASc and M-CHA2DS2-VASc scores can be assessed in patients diagnosed with COVID-19. These scores can predict mortality and the need for ICU hospitalization in these patients. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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Adolescent , Adult , Aged , Biomarkers , COVID-19 , Decision Support Techniques , Female , Fibrin Fibrinogen Degradation Products , Hospital Mortality , Hospitalization , Humans , Intensive Care Units , Length of Stay , Male , Middle Aged , Predictive Value of Tests , Prognosis , Receptors, Immunologic , Retrospective Studies , Risk Assessment , Risk Factors , Thromboembolism , Time Factors , Troponin I , Turkey , Young Adult , C reactive protein , D dimer , troponin I , biological marker , CRP protein, human , fibrin degradation product , fibrin fragment D , immunoglobulin receptor , troponin I , adult , aged , Article , CHA2DS2-VASc score , coronavirus disease 2019 , female , hospital mortality , hospitalization , human , intensive care unit , length of stay , major clinical study , male , mortality , predictive value , retrospective study , sensitivity and specificity , adolescent , blood , decision support system , middle aged , prognosis , risk assessment , risk factor , thromboembolism , time factor , turkey (bird) , young adult