CHA2DS2-VASc score and modified CHA2DS2-VASc score can predict mortality and intensive care unit hospitalization in COVID-19 patients

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dc.contributor.authorGunduz R.
dc.contributor.authorYildiz B.S.
dc.contributor.authorOzdemir I.H.
dc.contributor.authorCetin N.
dc.contributor.authorOzen M.B.
dc.contributor.authorBakir E.O.
dc.contributor.authorOzgur S.
dc.contributor.authorBayturan O.
dc.date.accessioned2024-07-22T08:05:48Z
dc.date.available2024-07-22T08:05:48Z
dc.date.issued2021
dc.description.abstractIn this study, we investigated whether the CHA2DS2-VASc score could be used to estimate the need for hospitalization in the intensive care unit (ICU), the length of stay in the ICU, and mortality in patients with COVID-19. Patients admitted to Merkezefendi State Hospital because of COVID-19 diagnosis confirmed by RNA detection of virus by using polymerase chain reaction between March 24, 2020 and July 6, 2020, were screened retrospectively. The CHA2DS2-VASc and modified CHA2DS2-VASc score of all patients was calculated. Also, we received all patients’ complete biochemical markers including D-dimer, Troponin I, and c-reactive protein on admission. We enrolled 1000 patients; 791 were admitted to the general medical service and 209 to the ICU; 82 of these 209 patients died. The ROC curves of the CHA2DS2-VASc and M-CHA2DS2-VASc scores were analyzed. The cut-off values of these scores for predicting mortality were ≥ 3 (2 or under and 3). The CHA2DS2-VASc and M-CHA2DS2-VASc scores had an area under the curve value of 0.89 on the ROC. The sensitivity and specificity of the CHA2DS2-VASc scores were 81.7% and 83.8%, respectively; the sensitivity and specificity of the M-CHA2DS2-VASc scores were 85.3% and 84.1%, respectively. Multivariate logistic regression analysis showed that CHA2DS2-VASc, Troponin I, D-Dimer, and CRP were independent predictors of mortality in COVID-19 patients. Using a simple and easily available scoring system, CHA2DS2-VASc and M-CHA2DS2-VASc scores can be assessed in patients diagnosed with COVID-19. These scores can predict mortality and the need for ICU hospitalization in these patients. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s11239-021-02427-1
dc.identifier.issn09295305
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13268
dc.language.isoEnglish
dc.publisherSpringer
dc.rightsAll Open Access; Hybrid Gold Open Access
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectBiomarkers
dc.subjectCOVID-19
dc.subjectDecision Support Techniques
dc.subjectFemale
dc.subjectFibrin Fibrinogen Degradation Products
dc.subjectHospital Mortality
dc.subjectHospitalization
dc.subjectHumans
dc.subjectIntensive Care Units
dc.subjectLength of Stay
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPredictive Value of Tests
dc.subjectPrognosis
dc.subjectReceptors, Immunologic
dc.subjectRetrospective Studies
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectThromboembolism
dc.subjectTime Factors
dc.subjectTroponin I
dc.subjectTurkey
dc.subjectYoung Adult
dc.subjectC reactive protein
dc.subjectD dimer
dc.subjecttroponin I
dc.subjectbiological marker
dc.subjectCRP protein, human
dc.subjectfibrin degradation product
dc.subjectfibrin fragment D
dc.subjectimmunoglobulin receptor
dc.subjecttroponin I
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectCHA2DS2-VASc score
dc.subjectcoronavirus disease 2019
dc.subjectfemale
dc.subjecthospital mortality
dc.subjecthospitalization
dc.subjecthuman
dc.subjectintensive care unit
dc.subjectlength of stay
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality
dc.subjectpredictive value
dc.subjectretrospective study
dc.subjectsensitivity and specificity
dc.subjectadolescent
dc.subjectblood
dc.subjectdecision support system
dc.subjectmiddle aged
dc.subjectprognosis
dc.subjectrisk assessment
dc.subjectrisk factor
dc.subjectthromboembolism
dc.subjecttime factor
dc.subjectturkey (bird)
dc.subjectyoung adult
dc.titleCHA2DS2-VASc score and modified CHA2DS2-VASc score can predict mortality and intensive care unit hospitalization in COVID-19 patients
dc.typeArticle

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