Quantitative Analysis of the Activity in Choroidal Neovascularizations after a Single Anti-VEGF Injection: OCT Versus OCT Angiography
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2021
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Abstract
Purpose: To analyze early quantitative changes in the choroidal neovascularization (CNV) area observed with optical coherence tomography angiography (OCTA) after single anti-vascular endothelial growth factor (anti-VEGF) injection. Materials and Methods: Treatment-naive patients with CNV secondary to neovascular age-related macular degeneration were analyzed immediately before and ~4 weeks after anti-VEGF injection. The primary endpoints of the study included changes in CNV total and vascular area. Secondary endpoints were best-corrected visual acuity (BCVA), central macular thickness (cMT), central total macular thickness (cTMT), and subfoveal choroidal thickness (SFCT). Results: A total of 27 patients (69.19 ± 5.91 years, 21 men/6 women, 14 type 1 NV, 11 type 2 NV, and 2 type 3 NV) were included in the study. There was a significant increase in BCVA and decreases in cMT, cTMT, and SFCT after treatment (p<0.05 for all). CNV total and vascular area changed by −11.55 ± 44.26% (95% confidence interval [CI]: −29.06 and 5.95; p=0.269) and −21.06 ± 41.2% (95% CI: −36.45/−5.67; p=0.786), respectively. The cases with decreased cTMT were accompanied by a decrease in CNV area only in 37% of the cases. No significant correlation was detected between cTMT and CNV total and vascular area percentage changes (r = −0.06, p=0.74; r = 0.02, p=0.9, respectively). Conclusions: Changes in CNV total and vascular area seem to have limited sensitivity as a biomarker in terms of activation, as wide variability was observed in CNV area after anti-VEGF injection. © 2021 Taylor & Francis.
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Angiogenesis Inhibitors , Choroidal Neovascularization , Female , Fluorescein Angiography , Humans , Infant , Infant, Newborn , Intravitreal Injections , Male , Retrospective Studies , Tomography, Optical Coherence , Visual Acuity , bevacizumab , dexamethasone , netilmicin , tropicamide , angiogenesis inhibitor , aged , Article , best corrected visual acuity , cataract extraction , central macular thickness , clinical article , comparative study , confidence interval , controlled study , diabetic retinopathy , eye surgery , female , follow up , human , male , observational study , optical coherence tomography angiography , patient referral , photodynamic therapy , prospective study , quantitative analysis , retina vein occlusion , retinal pigment epithelium , subfoveal choroidal thickness , subretinal fluid , subretinal neovascularization , fluorescence angiography , infant , intravitreal drug administration , newborn , optical coherence tomography , retrospective study , subretinal neovascularization , visual acuity