Quantitative Analysis of the Activity in Choroidal Neovascularizations after a Single Anti-VEGF Injection: OCT Versus OCT Angiography

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dc.contributor.authorAltinisik M.
dc.contributor.authorKurt E.
dc.contributor.authorKayikcioglu O.
dc.contributor.authorYildirim A.
dc.date.accessioned2024-07-22T08:06:35Z
dc.date.available2024-07-22T08:06:35Z
dc.date.issued2021
dc.description.abstractPurpose: To analyze early quantitative changes in the choroidal neovascularization (CNV) area observed with optical coherence tomography angiography (OCTA) after single anti-vascular endothelial growth factor (anti-VEGF) injection. Materials and Methods: Treatment-naive patients with CNV secondary to neovascular age-related macular degeneration were analyzed immediately before and ~4 weeks after anti-VEGF injection. The primary endpoints of the study included changes in CNV total and vascular area. Secondary endpoints were best-corrected visual acuity (BCVA), central macular thickness (cMT), central total macular thickness (cTMT), and subfoveal choroidal thickness (SFCT). Results: A total of 27 patients (69.19 ± 5.91 years, 21 men/6 women, 14 type 1 NV, 11 type 2 NV, and 2 type 3 NV) were included in the study. There was a significant increase in BCVA and decreases in cMT, cTMT, and SFCT after treatment (p<0.05 for all). CNV total and vascular area changed by −11.55 ± 44.26% (95% confidence interval [CI]: −29.06 and 5.95; p=0.269) and −21.06 ± 41.2% (95% CI: −36.45/−5.67; p=0.786), respectively. The cases with decreased cTMT were accompanied by a decrease in CNV area only in 37% of the cases. No significant correlation was detected between cTMT and CNV total and vascular area percentage changes (r = −0.06, p=0.74; r = 0.02, p=0.9, respectively). Conclusions: Changes in CNV total and vascular area seem to have limited sensitivity as a biomarker in terms of activation, as wide variability was observed in CNV area after anti-VEGF injection. © 2021 Taylor & Francis.
dc.identifier.DOI-ID10.1080/08820538.2021.1903944
dc.identifier.issn08820538
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13592
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd.
dc.subjectAngiogenesis Inhibitors
dc.subjectChoroidal Neovascularization
dc.subjectFemale
dc.subjectFluorescein Angiography
dc.subjectHumans
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectIntravitreal Injections
dc.subjectMale
dc.subjectRetrospective Studies
dc.subjectTomography, Optical Coherence
dc.subjectVisual Acuity
dc.subjectbevacizumab
dc.subjectdexamethasone
dc.subjectnetilmicin
dc.subjecttropicamide
dc.subjectangiogenesis inhibitor
dc.subjectaged
dc.subjectArticle
dc.subjectbest corrected visual acuity
dc.subjectcataract extraction
dc.subjectcentral macular thickness
dc.subjectclinical article
dc.subjectcomparative study
dc.subjectconfidence interval
dc.subjectcontrolled study
dc.subjectdiabetic retinopathy
dc.subjecteye surgery
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjectmale
dc.subjectobservational study
dc.subjectoptical coherence tomography angiography
dc.subjectpatient referral
dc.subjectphotodynamic therapy
dc.subjectprospective study
dc.subjectquantitative analysis
dc.subjectretina vein occlusion
dc.subjectretinal pigment epithelium
dc.subjectsubfoveal choroidal thickness
dc.subjectsubretinal fluid
dc.subjectsubretinal neovascularization
dc.subjectfluorescence angiography
dc.subjectinfant
dc.subjectintravitreal drug administration
dc.subjectnewborn
dc.subjectoptical coherence tomography
dc.subjectretrospective study
dc.subjectsubretinal neovascularization
dc.subjectvisual acuity
dc.titleQuantitative Analysis of the Activity in Choroidal Neovascularizations after a Single Anti-VEGF Injection: OCT Versus OCT Angiography
dc.typeArticle

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