The effect of erythropoietin on S100 protein expression in cochlea after acoustic overstimulation: An experimental study; [Eritropoetinin gürültü uygulaması sonrası kokleada s100 proteini ekspresyonuna etkisi: Deneysel Çalışma]
| dc.contributor.author | Gürgen S.G. | |
| dc.contributor.author | Gürgen O. | |
| dc.contributor.author | Kırkım G. | |
| dc.contributor.author | Kolatan H.E. | |
| dc.contributor.author | Gürkan S. | |
| dc.contributor.author | Eskiizmir G. | |
| dc.date.accessioned | 2025-04-10T11:10:53Z | |
| dc.date.available | 2025-04-10T11:10:53Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Aim: To investigate the effect of Erythropoietin on acoustically overstimu-lated rat spiral ganglion neurons (SGNs) using S100 protein immunostaining. Material and Method: Twenty-two Wistar albino rats were divided into three groups: healthy control group (n=7), Saline solution (n=7) and Erythropoietin injection groups (n=8). Saline solution and Erythropoietin injection groups re-ceived white noise (100 dB SPL) for 3 hours. Cochlear sections were stained by silver staining technique and immunostained by S100 antibody. Results: Histochemical analysis of silver staining sections revealed normal structure and a weak staining in SGNs of healthy control group. However, dark-black cytoplasmic staining, cellular shrinkage and degeneration were detected in saline injection group. On the other hand, a few weakly stained neurons were observed in erythropoietin injection group. S100 staining demonstrated strong reaction in Schwann cells and myelin sheaths of SGNs in healthy con-trol group (p<0.05). In saline solution injection group, Schwann cells showed moderate S100 reaction and other regions of SGNs showed weak reaction (p<0.05). In erythropoietin injection group, strong S100 expression almost similar to the healthy control group was determined, although there was an occasional decrease. Discussion: Erythropoetin may prevent noise induced SGN degeneration via protecting the Schwann cells in rat cochlea. © 2015, Journal of Clinical and Analytical Medicine. All rights reserved. | |
| dc.identifier.DOI-ID | 10.4328/JCAM.2009 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/49373 | |
| dc.publisher | Journal of Clinical and Analytical Medicine | |
| dc.title | The effect of erythropoietin on S100 protein expression in cochlea after acoustic overstimulation: An experimental study; [Eritropoetinin gürültü uygulaması sonrası kokleada s100 proteini ekspresyonuna etkisi: Deneysel Çalışma] | |
| dc.type | Article |