Prevalence of prescription of psychotropic drugs and drug-drug interactions: The cytochrome P450 system; [Psikotrop i̇laç yazilma sikliǧi ve i̇laç etkileşimleri: Sitokrom P450 sistemi]

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dc.contributor.authorDemet M.M.
dc.contributor.authorDeniz F.
dc.contributor.authorŞimşek E.
dc.contributor.authorTaşkin E.O.
dc.contributor.authorDeveci A.
dc.date.accessioned2024-07-22T08:24:50Z
dc.date.available2024-07-22T08:24:50Z
dc.date.issued2003
dc.description.abstractObjective: In this study, it is aimed to determine the prevalence of prescribing of psychotropic drugs and the combination of these drugs with the others, and to evaluate these combinations in terms of cytochrome p450 system interactions. Method: Out of 105 pharmacies in Manisa downtown area, fifty were visited. The sample consisted of 2164 prescriptions which had more than one drug. The combinations involved were recorded to a database and were evaluated according to cytochrome p450 system in terms of drug-drug interactions. Results: Of the whole prescriptions, 16.6% (360) had one or more psychotropic drug and the antidepressants were in first rank (9.3%) among psychotropic drugs. The number of prescriptions having any combination with possible drug-drug interactions was 19 (0.87% of the whole sample and 5.27% of the prescriptions which had psychotropic drug). Conclusion: It is a pleasing result that the amount of prescriptions that had possible drug-drug interactions in terms of cytochrome p450 system was small. Moreover, it is important that this study calls attention to possible drug interactions in terms of cytochrome system in addition to determine the present condition.
dc.identifier.issn10177833
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20155
dc.language.isoTurkish
dc.subjectalprazolam
dc.subjectantidepressant agent
dc.subjectantihistaminic agent
dc.subjectanxiolytic agent
dc.subjectastemizole
dc.subjectcarbamazepine
dc.subjectchlorpromazine
dc.subjectcholinergic receptor blocking agent
dc.subjectcitalopram
dc.subjectclarithromycin
dc.subjectclomipramine
dc.subjectcytochrome P450
dc.subjectdiazepam
dc.subjectfluoxetine
dc.subjectglucocorticoid
dc.subjecthaloperidol
dc.subjectimipramine
dc.subjectketoconazole
dc.subjectlansoprazole
dc.subjectmoclobemide
dc.subjectneuroleptic agent
dc.subjectneurotropic agent
dc.subjectomeprazole
dc.subjectparoxetine
dc.subjectproton pump inhibitor
dc.subjectpsychotropic agent
dc.subjectsertraline
dc.subjectterfenadine
dc.subjectthioridazine
dc.subjectunindexed drug
dc.subjectarticle
dc.subjectcombination chemotherapy
dc.subjectdrug interaction
dc.subjectdrug mechanism
dc.subjectdrug metabolism
dc.subjecthuman
dc.subjectprescription
dc.titlePrevalence of prescription of psychotropic drugs and drug-drug interactions: The cytochrome P450 system; [Psikotrop i̇laç yazilma sikliǧi ve i̇laç etkileşimleri: Sitokrom P450 sistemi]
dc.typeArticle

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