c-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression
| dc.contributor.author | Coskun, F | |
| dc.contributor.author | Ayhan, S | |
| dc.contributor.author | Tan, A | |
| dc.contributor.author | Isisag, A | |
| dc.date.accessioned | 2024-07-18T11:47:18Z | |
| dc.date.available | 2024-07-18T11:47:18Z | |
| dc.description.abstract | Context: Co-expressions of receptor tyrosine kinases such as c-MET and HER2 were reported in many studies. The concomitant expression is associated with more aggressive clinical course. Aims: In this study, it was intended to investigate the correlation of the positivity of c-MET and HER2 with histopathologic findings and their impacts on prognosis. Subjects and Methods: After the decision of the ethics committee, a total of 64 cases, whose HER 2 status was studied by dual silver in situ hybridization/immunohistochemistry method, were included in the study. Immunohistochemical staining for c-MET was performed to all cases and the evaluation was performed similarly to the criteria for HER2 evaluation, but cytoplasmic staining was also considered significant. Statistical Analysis Used: The data were analyzed using SPSS 20 for Windows. Results: c-MET positivity which is considered by the score of 2+ and 3+ was found only in 34.4% of HER2 positive cases while it was 59.3% in HER2 negative cases (P = 0.045). The sole histopathological feature associated with c-MET positivity was distal gastric localization (P = 0.016). Conclusions: Even though higher rates of c-MET positivity in HER2 positive cases were stated in the literature, contrary results were obtained in this study. Comparing the HER2+/c-MET + co-expression group with the other groups, no difference was found about age, sex, macroscopic and microscopic characteristics. The presence of c-MET positivity in cases with HER2 expression suggests that c-MET expression might be associated with the resistance to Trastuzumab. | |
| dc.identifier.issn | 0377-4929 | |
| dc.identifier.other | 0974-5130 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3426 | |
| dc.language.iso | English | |
| dc.publisher | WOLTERS KLUWER MEDKNOW PUBLICATIONS | |
| dc.subject | PROGNOSTIC-SIGNIFICANCE | |
| dc.subject | OVEREXPRESSION | |
| dc.subject | AMPLIFICATION | |
| dc.subject | CANCER | |
| dc.subject | SURVIVAL | |
| dc.subject | IMPACT | |
| dc.subject | EGFR | |
| dc.title | c-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression | |
| dc.type | Article |