Antileishmanial activity of selected Turkish medicinal plants

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dc.contributor.authorOzbilgin A.
dc.contributor.authorDurmuskahya C.
dc.contributor.authorKayalar H.
dc.contributor.authorErtabaklar H.
dc.contributor.authorGunduz C.
dc.contributor.authorUral I.O.
dc.contributor.authorZeyrek F.
dc.contributor.authorKurt O.
dc.contributor.authorCavus I.
dc.contributor.authorBalcıoglu C.
dc.contributor.authorToz S.O.
dc.contributor.authorOzbel Y.
dc.date.accessioned2025-04-10T11:11:10Z
dc.date.available2025-04-10T11:11:10Z
dc.date.issued2014
dc.description.abstractPurpose: To determine the in vitro and in vivo anti-leishmanial activities of extracts obtained from Centaurea calolepis, Phlomis lycia, Eryngium thorifolium, Origanum sipyleum and Galium incanum ssp. centrale.; Methods: To estimate the cytotoxicity of plant extracts, WST-1 assay was used. Parasite inhibition in the presence of plant extracts (25-500 μg/ml) in comparision with control group and reference group (glucantime, 25 μg/ml) at 12-72 h were determined in vitro on L. tropica promastigotes. The in vivo leishmanicidal activity of the extracts was evaluated against L. tropica-infected mice with glucantime as reference drug.; Results: The chloroform extract of Galium incanum ssp. centrale showed the highest cytotoxicity with IC50 value of 0.0316 ± 0.005 μg/ml. In vitro parasite inhibition by the plant extracts ranged between 16.7 ± 0.01 % and 100 ± 0.00 % at 25 μg/ml concentration. The methanol extract of Eryngium thorifolium possessed the highest activity on promastigotes of L. tropica with 100 % inhibition at 25 μg/ml. The water and chloroform extracts of C. calolepis and water and methanol extracts of E. thorifolium at a dose of 100 mg/kg reduced parasitaemia in L. tropica infected mice.; Conclusion: Parasite viability results suggest that the methanol extract of Eryngium thorifolium, regarded as non-cytotoxic, is a promising candidate drug for treating L. tropica infection. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.
dc.identifier.DOI-ID10.4314/tjpr.v13i12.15
dc.identifier.urihttp://hdl.handle.net/20.500.14701/49447
dc.publisherUniversity of Benin
dc.titleAntileishmanial activity of selected Turkish medicinal plants
dc.typeArticle

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