Tandem aza-Michael additions under high pressure: a shortcut to the azanorbornyl skeleton

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dc.contributor.authorRulev, AY
dc.contributor.authorYenil, N
dc.contributor.authorPesquet, A
dc.contributor.authorOulyadi, H
dc.contributor.authorMaddaluno, J
dc.date.accessioned2024-07-18T12:05:32Z
dc.date.available2024-07-18T12:05:32Z
dc.description.abstractThe hyperbaric aza-Michael addition of mono- and diamines on alpha,beta-unsaturated beta,beta-disubstituted mono- and diesters has been studied. While in the case of monoester, this reaction provides a beta-aminoester presenting a quaternary center, a direct and efficient access to diester or lactams featuring an azanorbornyl skeleton was obtained when starting from a diester, following an unprecedented double aza-Michael addition. (c) 2006 Elsevier Ltd. All rights reserved.
dc.identifier.issn0040-4020
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9826
dc.language.isoEnglish
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.subjectBETA-AMINO ACIDS
dc.subjectASYMMETRIC-SYNTHESIS
dc.subjectALPHA,BETA-ETHYLENIC ESTERS
dc.subjectCONJUGATE ADDITION
dc.subjectFACILE SYNTHESIS
dc.subjectALPHA-AMINO
dc.subjectEPIBATIDINE
dc.subjectDERIVATIVES
dc.subjectLACTAMS
dc.subjectACTIVATION
dc.titleTandem aza-Michael additions under high pressure: a shortcut to the azanorbornyl skeleton
dc.typeArticle

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