Methyl cellulose/okra mucilage composite films, functionalized with Hypericum perforatum oil and gentamicin, as a potential wound dressing
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Date
2024
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Abstract
There is a growing demand for the development of functional wound dressings enriched with bioactive natural compounds to improve the quality of life of the population by accelerating the healing process of chronic wounds. In this regard, a functional composite film of okra mucilage (OM) and methylcellulose (MC) incorporated with Hypericum perforatum oil (Hp) and gentamicin (G) was prepared and characterized as a wound dressing. Increasing Hp resulted in improved film properties with a more porous structure, higher WVTR, and lower surface hydrophobicity. Furthermore, incorporating Hp into OM:MC films led to increased elongation at the break while reducing the tensile strength of the films. The highest values of total antioxidant capacity (1.09–1.16 mM trolox equivalent) and total phenolic content (13.76–16.94 μg GA equivalent mL−1) were measured in the composite films containing the highest Hp concentration (1.5 %). In addition, OM:MC/HpG composite films exhibited significant antibacterial activity against both E. coli and S. aureus and prevented the transmission of these bacteria through the films. Hp incorporation reduced the cytotoxic effects of OM:MC films on BJ cells and increased the wound closure rate in vitro. In conclusion, the developed OM:MC/HpG composite film can be a promising candidate as a novel wound dressing with its superior properties. © 2023
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Capacity , Film , Methyl Cellulose , Oil , Okra , Surgical Dressings , Tensile Strength , Water Repellence , Abelmoschus , Anti-Bacterial Agents , Bandages , Escherichia coli , Gentamicins , Hypericum , Methylcellulose , Plant Oils , Polysaccharides , Quality of Life , Staphylococcus aureus , Cellulose films , Escherichia coli , Tensile strength , gentamicin , Hypericum perforatum oil , phenol derivative , trolox C , unclassified drug , vegetable oil , antiinfective agent , gentamicin , methylcellulose , polysaccharide , vegetable oil , Bioactive natural compounds , Composite wound dressing , Functionalized , Gentamicin , Growing demand , Hypericum perforatum , Methyl cellulose , Methylcellulose , Okra mucilage , Wound dressings , antibacterial activity , Article , concentration (parameter) , controlled study , cytotoxicity , Escherichia coli , hydrophobicity , Hypericum perforatum , mucilage , nonhuman , porosity , Staphylococcus aureus , surface property , tensile strength , total antioxidant capacity , water vapor , Abelmoschus , chemistry , Hypericum , microbiology , quality of life , Cellulose