Methyl cellulose/okra mucilage composite films, functionalized with Hypericum perforatum oil and gentamicin, as a potential wound dressing

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dc.contributor.authorCoban S.N.
dc.contributor.authorPolatoglu I.
dc.contributor.authorEroglu E.
dc.date.accessioned2024-07-22T08:02:11Z
dc.date.available2024-07-22T08:02:11Z
dc.date.issued2024
dc.description.abstractThere is a growing demand for the development of functional wound dressings enriched with bioactive natural compounds to improve the quality of life of the population by accelerating the healing process of chronic wounds. In this regard, a functional composite film of okra mucilage (OM) and methylcellulose (MC) incorporated with Hypericum perforatum oil (Hp) and gentamicin (G) was prepared and characterized as a wound dressing. Increasing Hp resulted in improved film properties with a more porous structure, higher WVTR, and lower surface hydrophobicity. Furthermore, incorporating Hp into OM:MC films led to increased elongation at the break while reducing the tensile strength of the films. The highest values of total antioxidant capacity (1.09–1.16 mM trolox equivalent) and total phenolic content (13.76–16.94 μg GA equivalent mL−1) were measured in the composite films containing the highest Hp concentration (1.5 %). In addition, OM:MC/HpG composite films exhibited significant antibacterial activity against both E. coli and S. aureus and prevented the transmission of these bacteria through the films. Hp incorporation reduced the cytotoxic effects of OM:MC films on BJ cells and increased the wound closure rate in vitro. In conclusion, the developed OM:MC/HpG composite film can be a promising candidate as a novel wound dressing with its superior properties. © 2023
dc.identifier.DOI-ID10.1016/j.ijbiomac.2023.127757
dc.identifier.issn01418130
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11758
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.subjectCapacity
dc.subjectFilm
dc.subjectMethyl Cellulose
dc.subjectOil
dc.subjectOkra
dc.subjectSurgical Dressings
dc.subjectTensile Strength
dc.subjectWater Repellence
dc.subjectAbelmoschus
dc.subjectAnti-Bacterial Agents
dc.subjectBandages
dc.subjectEscherichia coli
dc.subjectGentamicins
dc.subjectHypericum
dc.subjectMethylcellulose
dc.subjectPlant Oils
dc.subjectPolysaccharides
dc.subjectQuality of Life
dc.subjectStaphylococcus aureus
dc.subjectCellulose films
dc.subjectEscherichia coli
dc.subjectTensile strength
dc.subjectgentamicin
dc.subjectHypericum perforatum oil
dc.subjectphenol derivative
dc.subjecttrolox C
dc.subjectunclassified drug
dc.subjectvegetable oil
dc.subjectantiinfective agent
dc.subjectgentamicin
dc.subjectmethylcellulose
dc.subjectpolysaccharide
dc.subjectvegetable oil
dc.subjectBioactive natural compounds
dc.subjectComposite wound dressing
dc.subjectFunctionalized
dc.subjectGentamicin
dc.subjectGrowing demand
dc.subjectHypericum perforatum
dc.subjectMethyl cellulose
dc.subjectMethylcellulose
dc.subjectOkra mucilage
dc.subjectWound dressings
dc.subjectantibacterial activity
dc.subjectArticle
dc.subjectconcentration (parameter)
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectEscherichia coli
dc.subjecthydrophobicity
dc.subjectHypericum perforatum
dc.subjectmucilage
dc.subjectnonhuman
dc.subjectporosity
dc.subjectStaphylococcus aureus
dc.subjectsurface property
dc.subjecttensile strength
dc.subjecttotal antioxidant capacity
dc.subjectwater vapor
dc.subjectAbelmoschus
dc.subjectchemistry
dc.subjectHypericum
dc.subjectmicrobiology
dc.subjectquality of life
dc.subjectCellulose
dc.titleMethyl cellulose/okra mucilage composite films, functionalized with Hypericum perforatum oil and gentamicin, as a potential wound dressing
dc.typeArticle

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