Secondhand tobacco smoke and severity in wheezing children: Nasal oxidant stress and inflammation

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dc.contributor.authorYilmaz O.
dc.contributor.authorTurkeli A.
dc.contributor.authorOnur E.
dc.contributor.authorBilge S.
dc.contributor.authorYuksel H.
dc.date.accessioned2024-07-22T08:09:44Z
dc.date.available2024-07-22T08:09:44Z
dc.date.issued2018
dc.description.abstractObjectives: Prenatal and postnatal smoke exposures are associated with many lung diseases in children due to impaired lung function, increased inflammation, and oxidative stress. We aimed to determine the influence of secondhand tobacco smoke exposure on the levels of nasal glutathione, IL-8, IL-17, MMP-9, and TIMP-1, as well as serum surfactant protein-D (SP-D) in wheezy children. Methods: We enrolled 150 children with recurrent wheezing and recorded wheezing characteristics at enrollment. We measured the levels of serum cotinine, SP-D, nasal glutathione, IL-8, IL-17, MMP-9, and TIMP-1. Serum cotinine levels between 3 and 12 ng/mL, and above 12 ng/mL were defined as lower and higher level secondhand tobacco smoke exposure, respectively. The ANOVA test, Pearson's correlation analysis and multivariate analysis with a linear regression test were used for the statistical analysis. Results: Ninety-one children had been exposed to lower level secondhand tobacco smoke, while 24 children were exposed to higher level secondhand tobacco smoke. Thirty-five children were not exposed to cigarette smoke. Wheezing symptom scores were higher in exposed children (p = 0.03). Levels of other biomarkers showed no significant difference. Conclusions: Secondhand tobacco smoke exposure is associated with more severe respiratory symptoms in wheezing children. However, levels of nasal or serum inflammatory markers fail to explain this association, either because of different mechanical factors in the process or due to low levels of the biomarkers especially in nasal secretions. © 2018 Taylor & Francis Group, LLC.
dc.identifier.DOI-ID10.1080/02770903.2017.1350970
dc.identifier.issn02770903
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14946
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd
dc.subjectChild, Preschool
dc.subjectCotinine
dc.subjectCytokines
dc.subjectEnvironmental Exposure
dc.subjectFemale
dc.subjectGlutathione
dc.subjectHumans
dc.subjectInfant
dc.subjectMale
dc.subjectMaternal-Fetal Exchange
dc.subjectMatrix Metalloproteinase 9
dc.subjectMothers
dc.subjectNasal Mucosa
dc.subjectOxidative Stress
dc.subjectPregnancy
dc.subjectPulmonary Surfactant-Associated Protein D
dc.subjectRespiratory Sounds
dc.subjectSeverity of Illness Index
dc.subjectTissue Inhibitor of Metalloproteinase-1
dc.subjectTobacco Smoke Pollution
dc.subjectbiological marker
dc.subjectcigarette smoke
dc.subjectcotinine
dc.subjectgelatinase B
dc.subjectglutathione
dc.subjectinterleukin 17
dc.subjectinterleukin 8
dc.subjectsurfactant protein D
dc.subjecttissue inhibitor of metalloproteinase 1
dc.subjecttobacco smoke
dc.subjectcotinine
dc.subjectcytokine
dc.subjectgelatinase B
dc.subjectglutathione
dc.subjectMMP9 protein, human
dc.subjectsurfactant protein D
dc.subjecttissue inhibitor of metalloproteinase 1
dc.subjectArticle
dc.subjectbiochemical analysis
dc.subjectblood level
dc.subjectchild
dc.subjectcontrolled study
dc.subjectcorrelation coefficient
dc.subjectdisease severity
dc.subjectexposure
dc.subjectfemale
dc.subjecthuman
dc.subjectinflammation
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmultivariate analysis
dc.subjectnasal lavage
dc.subjectoxidative stress
dc.subjectpassive smoking
dc.subjectwheezing
dc.subjectabnormal respiratory sound
dc.subjectanalysis
dc.subjectblood
dc.subjectenvironmental exposure
dc.subjectfetomaternal transfusion
dc.subjectinfant
dc.subjectmetabolism
dc.subjectmother
dc.subjectnose mucosa
dc.subjectoxidative stress
dc.subjectpassive smoking
dc.subjectpregnancy
dc.subjectpreschool child
dc.subjectseverity of illness index
dc.titleSecondhand tobacco smoke and severity in wheezing children: Nasal oxidant stress and inflammation
dc.typeArticle

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