Increased vitamin D binding protein levels are associated with irritable bowel syndrome
| dc.contributor.author | Elif BÖREKÇİ | |
| dc.contributor.author | Mahmut KILIÇ | |
| dc.contributor.author | Zeynep OZAN | |
| dc.contributor.author | Hasan BÖREKÇİ | |
| dc.contributor.author | Tekin YILDIRIM | |
| dc.contributor.author | Yeşim GÖÇMEN | |
| dc.contributor.author | Hatice BAŞ | |
| dc.date.accessioned | 2024-07-24T09:10:39Z | |
| dc.date.available | 2024-07-24T09:10:39Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | identify Irritable bowel syndrome (IBS) and its subtypes. The aim of this study is to explore potential serum biomarkers that may be associated with IBS subtypes, particularly in the vitamin D pathway. Methods: The study population comprised 75 IBS patients and 79 controls. Patients divided into IBS subtypes. Routine biochemical parameters, 25-OH-vitamin D, vitamin D binding protein (VDBP) and vitamin D receptor (VDR) serum levels were compared between IBS subtypes and controls. Factors related to IBS subtypes were examined by multivariate logistic regression analysis. Results: Vitamin D levels were lower; VDBP and VDR were higher in all IBS patients than in controls (p<0.001; 0.047 and 0.029, respectively). According to logistic regression analysis, VDBP was a disease-related parameter as much as vitamin D in all IBS subtypes. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were higher especially in diarrhea-dominant IBS (IBS-D) (p=0.041; 0.046) and vitamin B12 were significantly lower in constipation-dominant IBS (IBS-C) (p=0.001). Conclusions: Increased VDBP levels were associated with all IBS subtypes. Patients, especially in IBS-D, had higher serum levels of VDBP, CRP and ESR. Vitamin B12 deficiency, which we consider as a result of the disease, was more common in IBS-C. | |
| dc.identifier.DOI-ID | 10.1515/tjb-2020-0305 | |
| dc.identifier.issn | 1303-829X | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/23094 | |
| dc.language.iso | eng | |
| dc.title | Increased vitamin D binding protein levels are associated with irritable bowel syndrome | |
| dc.type | Araştırma Makalesi |