A Star of Connection Between Pancreatic Cancer and Diabetes: Adrenomedullin

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dc.contributor.authorGörgülü, K
dc.contributor.authorDiakopoulos, KN
dc.contributor.authorVatansever, HS
dc.date.accessioned2024-07-18T12:02:48Z
dc.date.available2024-07-18T12:02:48Z
dc.description.abstractPancreatic cancer belongs to the most aggressive cancer types, with an incidence rate equallig mortality rate. It is well-known that type 2 diabetes is a significant risk factor for pancreatic cancer. Interestingly, several studies have shown that pancreatic cancer can also lead to type 2 diabetes, as part of the pancreatic cancer induced paraneoplastic syndrome. Multiple factors have been proposed to be involved in the interaction between pancreatic cancer and diabetes. Adrenomedullin, a multifunctional hormone, is nominated as a strong candidate influencing the connection of pancreatic cancer with diabetes. Evidence so far suggest that adrenomedullin upregulation is linked with pancreatic cancer growth, invasion, metastasis, and angiogenesis. Most importantly, adrenomedullin exerts paracrine effects on pancreatic beta cells impairing insulin secretion, causing glucose intolerance, and thus leading to beta cell dysfunction. This review will explain recent advances regarding the involvement of adrenomedullin in pancreatic cancer and pancreatic cancer-associated diabetes.
dc.identifier.issn1590-8577
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8673
dc.language.isoEnglish
dc.publisherE S BURIONI RICERCHE BIBLIOGRAFICHE
dc.subjectUP-REGULATION
dc.subjectCELLS
dc.subjectAPOPTOSIS
dc.subjectHYPOXIA
dc.subjectANGIOGENESIS
dc.subjectINVASION
dc.subjectGROWTH
dc.subjectMICE
dc.subjectANTAGONIST
dc.subjectACTIVATION
dc.titleA Star of Connection Between Pancreatic Cancer and Diabetes: Adrenomedullin
dc.typeReview

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