Effect of intra-abdominal boric acid in the experimental adhesion model
| dc.contributor.author | Rıdvan Barkın KABALAR | |
| dc.contributor.author | Semra TUTCU ŞAHİN | |
| dc.contributor.author | Semin AYHAN | |
| dc.date.accessioned | 2024-07-24T09:14:47Z | |
| dc.date.available | 2024-07-24T09:14:47Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | BACKGROUND: The continuous advancement in medical and surgical techniques has led to a rise in the frequency of abdominal operations, subsequently increasing the incidence of intra-abdominal adhesions. Over 90% of laparotomies result in postoperative intra-abdominal adhesions. This study investigates the effect of a 5% boric acid solution on the development of intra-abdominal adhe- sions in rats, using an adhesion model. METHODS: This study was conducted with two groups: a control group, in which the adhesion model was applied without any treat- ment, and a boric acid group, which was treated with a 5% boric acid solution. Each group comprised 16 rats. On the 14th postopera- tive day, the rats were sacrificed, re-explored, and the developed adhesions were evaluated both macroscopically and microscopically. The data from macroscopic and microscopic scoring were analyzed using the Mann-Whitney U test in the IBM Statistical Package for the Social Sciences (SPSS) Statistics 24 program. A p-value of less than 0.05 was considered statistically significant. This research was supported by the Manisa Celal Bayar University Scientific Research Projects Commission. RESULTS: A statistically significant difference was observed between the boric acid-treated group and the control group, with the boric acid group showing a significant decrease in adhesion development both macroscopically and microscopically (p<0.05). CONCLUSION: In the future, boron could play a significant role in reducing and preventing intra-abdominal adhesions after sur- gery. This investigation could pave the way for further research into the mechanism by which boric acid prevents the development of intra-abdominal adhesions. Moreover, it is imperative to explore the potential side effects of intra-abdominal boron application at the optimum concentration of the solution. | |
| dc.identifier.DOI-ID | 10.14744/tjtes.2024.77767 | |
| dc.identifier.issn | 1306-696X | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/26350 | |
| dc.language.iso | eng | |
| dc.title | Effect of intra-abdominal boric acid in the experimental adhesion model | |
| dc.type | Diğer |