Etiology and outcome of acute kidney injury in children

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dc.contributor.authorDuzova, A
dc.contributor.authorBakkaloglu, A
dc.contributor.authorKalyoncu, M
dc.contributor.authorPoyrazoglu, H
dc.contributor.authorDelibas, A
dc.contributor.authorOzkaya, O
dc.contributor.authorPeru, H
dc.contributor.authorAlpay, H
dc.contributor.authorSoylemezoglu, O
dc.contributor.authorGur-Guven, A
dc.contributor.authorBak, M
dc.contributor.authorBircan, Z
dc.contributor.authorCengiz, N
dc.contributor.authorAkil, I
dc.contributor.authorOzcakar, B
dc.contributor.authorUncu, N
dc.contributor.authorKarabay-Bayazit, A
dc.contributor.authorSonmez, F
dc.date.accessioned2024-07-18T12:08:19Z
dc.date.available2024-07-18T12:08:19Z
dc.description.abstractThe aim of this prospective, multicenter study was to define the etiology and clinical features of acute kidney injury (AKI) in a pediatric patient cohort and to determine prognostic factors. Pediatric-modified RIFLE (pRIFLE) criteria were used to classify AKI. The patient cohort comprised 472 pediatric patients (264 males, 208 females), of whom 32.6% were newborns (median age 3 days, range 1-24 days), and 67.4% were children aged > 1 month (median 2.99 years, range 1 month-18 years). The most common medical conditions were prematurity (42.2%) and congenital heart disease (CHD, 11.7%) in newborns, and malignancy (12.9%) and CHD (12.3%) in children aged > 1 month. Hypoxic/ischemic injury and sepsis were the leading causes of AKI in both age groups. Dialysis was performed in 30.3% of newborns and 33.6% of children aged > 1 month. Mortality was higher in the newborns (42.6 vs. 27.9%; p < 0.005). Stepwise multiple regression analysis revealed the major independent risk factors to be mechanical ventilation [relative risk (RR) 17.31, 95% confidence interval (95% CI) 4.88-61.42], hypervolemia (RR 12.90, 95% CI 1.97-84.37), CHD (RR 9.85, 95% CI 2.08-46.60), and metabolic acidosis (RR 7.64, 95% CI 2.90-20.15) in newborns and mechanical ventilation (RR 8.73, 95% CI 3.95-19.29), hypoxia (RR 5.35, 95% CI 2.26-12.67), and intrinsic AKI (RR 4.91, 95% CI 2.04-11.78) in children aged > 1 month.
dc.identifier.issn0931-041X
dc.identifier.other1432-198X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10886
dc.language.isoEnglish
dc.publisherSPRINGER
dc.subjectACUTE-RENAL-FAILURE
dc.subjectCRITICALLY-ILL CHILDREN
dc.subjectFLUID OVERLOAD
dc.subjectRISK-FACTORS
dc.subjectPROGNOSIS
dc.subjectEXPERIENCE
dc.subjectDIALYSIS
dc.subjectMORTALITY
dc.subjectSURVIVAL
dc.subjectMODALITY
dc.titleEtiology and outcome of acute kidney injury in children
dc.typeArticle

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