Carbapenem versus fosfomycin tromethanol in the treatment of extended-spectrum beta-lactamase-producing Escherichia coli-related complicated lower urinary tract infection
| dc.contributor.author | Senol S. | |
| dc.contributor.author | Tasbakan M. | |
| dc.contributor.author | Pullukcu H. | |
| dc.contributor.author | Sipahi O.R. | |
| dc.contributor.author | Sipahi H. | |
| dc.contributor.author | Yamazhan T. | |
| dc.contributor.author | Arda B. | |
| dc.contributor.author | Ulusoy S. | |
| dc.date.accessioned | 2025-04-10T11:15:46Z | |
| dc.date.available | 2025-04-10T11:15:46Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | The aim of this observational prospective study was to compare the effect of fosfomycin tromethanol (FT) and carbapenems (meropenem or imipenem cilastatin) in the treatment of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli-related complicated lower urinary tract infection (CLUTI). Inclusion criteria were: patients who were aged >18 yr with dysuria or problems with frequency or urgency in passing urine; those with >20 leukocytes/mm3 in urine microscopy and culture-proven ESBL-producing carbapenem or FT-sensitive E. coli in the urine (>10 5 cfu/mm3); no leukocytosis or fever; and who were treated with FT (oral 3 g sachet x 1 every other night, three times) or carbapenems between March 2005 and January 2006 in our outpatient clinic and hospital. A total of 47 CLUTI attacks in 47 patients (27 FT group, 20 carbapenem group) were observed prospectively. Clinical and microbiological success in the carbapenem and FT groups was similar (19/20 vs 21/27 and 16/20 vs 16/27 p>0.05). Drug acquisition costs were significantly lower in the FT group (p<0.001). Although it is not a randomized controlled study, these data show that FT may be a suitable, effective and cheap alternative in the treatment of ESBL-producing E. coli-related CLUTI. © E.S.I.F.T. srl. | |
| dc.identifier.DOI-ID | 10.1179/joc.2010.22.5.355 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/51280 | |
| dc.publisher | Maney Publishing | |
| dc.title | Carbapenem versus fosfomycin tromethanol in the treatment of extended-spectrum beta-lactamase-producing Escherichia coli-related complicated lower urinary tract infection | |
| dc.type | Article |